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Kim, Eom, Yoon, and Kim: Clinical Analysis of Findings for Anterior Segment Optical Coherent Tomography in Recurrent Corneal Erosion Syndrome
Original Article

Journal of the Korean Ophthalmological Society 2019; 60(12): 1155-1161.

Published online: 17 December 2019

DOI: https://doi.org/10.3341/jkos.2019.60.12.1155

Clinical Analysis of Findings for Anterior Segment Optical Coherent Tomography in Recurrent Corneal Erosion Syndrome

Yu Min Kim, MD, Hee Dong Eom, MD, Dong Hee Yoon, MD, Hong Kyun Kim, MD, PhD

Department of Ophthalmology, School of Medicine, Kyungpook National University, Daegu, Korea.

Address reprint requests to Hong Kyun Kim, MD, PhD. Department of Ophthalmology, School of Medicine, Kyungpook National University, #130 Dongdeok-ro, Jung-gu, Daegu 41944, Korea. Tel: 82-53-420-5816, Fax: 82-53-426-6552, okeye@knu.ac.kr

Received 4 July 2019       Revised 16 August 2019       Accepted 6 December 2019

©2019 The Korean Ophthalmological Society

The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate the correlation between abnormal findings seen in anterior segment optical coherent tomography and the recurrence rate in patients with recurrent corneal erosion syndrome.

Methods

Between January 2015 and August 2018, 53 eyes of 52 patients who had been diagnosed with recurrent corneal erosion syndrome were included in the study. Follow-up was performed for 12 months. To confirm the recurrence, we questioned the subjects on their symptoms and performed slit lamp examinations. At the first visit, the second week, and the first month, we performed anterior segment optical coherent tomography to identify pathologic findings for recurrent corneal erosion syndrome.

Results

In 12 months, 29 eyes (54.7%) had a recurrence of corneal erosion and 24 eyes (45.3%) had no recurrence. There was no significant difference in age, sex, trauma, diabetes mellitus, or meibomian gland dysfunction between the recurrent and non-recurrent groups. Among the anterior segment optical coherent tomography findings, anterior stromal hyper-reflectivity, undetected epithelial basement membrane, intraepithelial basement membrane, intraepithelial inclusions were not significantly different between the two groups. In the first month, corneal epithelial edema was 82.8% in the recurrent group, but 33.3% in the non-recurrent group. It was significantly different (p = 0.000). Corneal epithelial thickness lowered significantly in the non-recurrent group, but not in the recurrent group in the first month. In other words, epithelial edema improved in the non-recurrent group, whereas epithelial edema did not improve in the recurrent group.

Conclusions

If corneal epithelial edema is not treated in patients with recurrent corneal erosion syndrome, high possibility of a recurrence should be considered.

Keywords: Corneal edema, Corneal epithelial edema, Corneal epithelial thickness, Corneal epithelium, Recurrent corneal erosion

Figures and Tables

Figure 1

Anterior segment optical coherent tomography of theright cornea. Anterior stromal hyper-reflectivity bellow affectedepithelium (arrow), intraepithelial inclusion (arrowhead),and undetected epithelial basement membrane (asterisk).

jkos-60-1155-g001
Figure 2

Change in the corneal epithelial thickness. A comparisonof the corneal epithelial thickness between the recurrentgroup and the non-recurrent group. *Wilcoxon signed rank test.

jkos-60-1155-g002
Table 1

Demographic characteristics and clinical features ofthe patients with recurrent corneal erosion syndrome

jkos-60-1155-i001

Values are presented as mean ± standard deviation (range) or number (%).

DM = diabetes mellitus; MGD = meibomian gland dysfunction.

Table 2

Demographic characteristics and clinical features of the recurrent group and the non-recurrent group

jkos-60-1155-i002

Values are presented as mean ± standard deviation or number (%).

DM = diabetes mellitus; MGD = meibomian gland dysfunction.

*Mann-Whitney U test; †chi-square test; ‡Fisher's exact test.

Table 3

Comparison of anterior segment optical coherent tomography findings in recurrent corneal erosion syndrome of the recurrentgroup and the non-recurrent group

jkos-60-1155-i003

Values are presented as number (%).

*Chi-square test.

Table 4

Alteration of corneal epithelial thickness of the recurrentgroup and the non-recurrent group

jkos-60-1155-i004

Values are presented as mean ± standard deviation.

*Mann-Whitney U test.

Table 5

Comparison of recurrence rate depending on corneal epithelial thickness of 60 µm at 1 month

jkos-60-1155-i005

Values are presented as number (%).

*Chi-square test.

Notes

Conflicts of Interest The authors have no conflicts to disclose.

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