Eun Hye Lee; Tae Kyung Lee; JoonHo Lee

doi:10.14734/PN.2019.30.2.110

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Lee, Lee, and Lee: Behçet's Disease with Deep Vaginal Ulcer Diagnosed for the First Time during Pregnancy

Case Report

Perinatology 2019;30(2):110-115.

Published online: 4 June 2019

DOI: https://doi.org/10.14734/PN.2019.30.2.110

Behçet's Disease with Deep Vaginal Ulcer Diagnosed for the First Time during Pregnancy

Eun Hye Lee, MD, Tae Kyung Lee, MD, JoonHo Lee, MD, PhD

Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Yonsei University Health system, Seoul, Korea

Correspondence to JoonHo Lee, MD, PhD Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Yonsei University Health system, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea Tel: +82-2-2228-2239 Fax: +82-2-313-8350 E-mail: jleemd@yuhs.ac

Received 13 October 2018 Revised 22 October 2018 Accepted 24 October 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Behçet's disease is a chronic multisystem inflammatory disease characterized by recurrent oral ulcer, genital ulcer and ocular inflammation. It affects mainly young adults ranging from twenties to forties, so the relationship between Behçet's disease and pregnancy has been investigated in women during reproductive ages. In pregnant women, genital ulcers arise from infectious and noninfectious causes. We report a case of a Behçet's disease with deep vaginal ulcer diagnosed for the first time during pregnancy.

Keywords: Behçet's disease, Deep vaginal ulcer, Pregnancy

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Fig. 1.

Deep vaginal ulcerative lesion. Deep vaginal ulcer was observed right above 11 o'clock of the uterine cervix.

Fig. 2.

(A) Peri-urethral orifice genital ulcer. Genital ulcer was shown above urethral orifice. (B) Peri-urethral orifice genital ulcer. Genital ulcer was displayed below the urethral orifice. (C) Deep vaginal ulcer with purulent discharge. Deep vaginal ulcer was aggravated with purulent discharge.

Fig. 3.

(A) Clear uterine cervix without genital ulcer. Previous deep vaginal ulcer above the uterine cervix disappeared and clear uterine cervix was shown. (B) Vaginal cavity was clear without genital ulcer.

Table 1.

Diagnostic Criteria for Behçet's Disease¹⁷

Criterion	Required features
Recurrent oral ulceration	Minor aphthous, major aphthous, or herpetiform ulceration observed by physician or patient, which recurred at least 3 times in one 12-month period
Plus any two of the following:
Recurrent genital ulceration	Aphthous ulceration or scarring, observed by clinician or patient
Eye lesions	Anterior uveitis, posterior uveitis, or cells in vitreous on slit lamp examination; or retinal vasculitis observed by ophthalmologist
Skin lesions	Erythema nodosum observed by physician or patient, pseudofolliculitis, or papulopustular lesions; or acneiform nodules observed by physician in postadolescent patients not on corticosteroid treatment
Pathergy test	Read by physician at 24–48 hours

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