Since Moore diagnosed brain tumor with radioiodine labelled fluoroscein in 1948, many authors have reportedhigh diagnostic accuracy of brain scanning with radioisotope of P, 42K, Bi, Hg, 99mTc etc. In 1967, Stern andWagner first described 113mIn chelate, and other authors reported clinical value of 11mIn DTPA for brain scanning.Since February, 1970, 140 113mIn brain scan have been carried out and analyzed at Dept. of Radiology and Nuclearmedicine of Yonsei University. Results : 1 49 cases(35) out of 140 brain scanning, 59(67%) out of 85 cases withscan and angiography, 14 cases(56%) out of 25 cases with scan and PVG, 35 cases(73%) out of 48 cases with scan andEEG, and 40 cases(29%) out of 138 cases with scan and plain skull disclosed abnormality. 2. In 47 cases of 140brain scans diagnoses were confirmed by surgery and pathology. Among them 36 cases had abnormal brain scanning. 3.In the aspect of pathological analysis, 27 brain neoplasms were diagnosed out of 47 confirmed cases. Diagnosticaccuracy, 93% by brain scan, 91% angiography, 78% by PVG, 89% by EEG, and 58% by plain skull were confirmed. 4.McGinnis' classification of scan findings was much helpful for diagnosis of characteristic intracranial disease.In viewing the above, brain scan is much better to detect optical accuracy in size, shape and location ofintracranial lesions without premedication; therefore the scan is easier for any type of patients includingemergency without complication. On comparison with other radioactive isotope, In-113m DTPA tracer for brain scanmakes not only good resolution for scan image, but also dose not collect in the othter organ such as choroidplexuses.