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Hwang and Cha: Orbital Rim Uptake on Bone Scans and Its Clinical Significance
Original Article

J Korean Soc Radiol 2019;80(1):81-87.

Published online: 20 January 2019

DOI: https://doi.org/10.3348/jksr.2019.80.1.81

Orbital Rim Uptake on Bone Scans and Its Clinical Significance

Yeong Uk Hwang, MD, Soon Joo Cha, MD∗

Department of Radiology, Inje University Ilsan Paik Hospital, Goyang, Korea

∗Corresponding author Soon Joo Cha, MD Department of Radiology, Inje University Ilsan Paik Hospital, 170 Juhwa-ro, Ilsanseo-gu, Goyang 10380, Korea. Tel 82-31-910-7394 Fax 82-31-910-7843 E-mail chasoonj@paik.ac.kr

Received 11 October 2016       Revised 25 August 2017       Accepted 25 November 2018

Copyright © 2019 The Korean Society of Radiology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study is to evaluate orbital rim uptake on bone scan and to discuss their clinical significance.

Materials and Methods

From January 2011 to August 2013, 3149 cases of bone scans were analyzed to check for existence of uptake abnormalities in the orbital rim with relative size and position. The bone scans were compared with either positron emission tomography-computed tomography (PET/CT) or computed tomography (CT). For cases without other imaging examinations, comparisons were made with other bone scans.

Results

In total, 13 cases of the orbital rib uptake were ultimately evaluated. In 6 cases, the intake abnormalities of the orbital rim appeared in superior lateral aspect of the orbital rim to occupy the highest frequency (46.2%). Distinctively, bone scans showed no abnormal uptake in medial and inferior aspect of orbital rim. The 10 cases are compared with PET/CT or CT and as a result, there are no abnormalities that correspond to the orbital lesions of bone scans. The 3 cases were compared with other bone scans and no changes in the orbital lesions were confirmed between the bone scans.

Conclusion

There is an unilateral, small, focal orbital rim uptake on bone scans to be possibility of nonspecific benign lesions.

References

1. Moon DH, Ryu JS. Recent advances in musculoskeletal nuclear medicine.J Korean Med Assoc. 2003; 46:196–203.
2. Sohn MH. Normal variants and artifacts in bone scan: potential for errors in interpretation.Korean J Nucl Med. 2004; 38:1–20.
3. Thang SP, Tan AE, Goh AS. Bone scan “Hot Spot” at the superior lateral orbital margin fronto-zygomatic suture uptake characterized with Tc-99m MDP SPECT/CT.World J Nucl Med. 2011; 10:139–140.
4. Swie˛taszczyk C, Pilecki SE. Enhanced accumulation of bone seekers at superior lateral orbital margin: potential origin.World J Nucl Med. 2014; 13:3–5.
5. Senda K, Itoh S. Evaluation of diffusely high uptake by the calvaria in bone scintigraphy.Ann Nucl Med. 1987; 1:23–26.
6. Suematsu T, Yoshida S, Motohara T, Fujiwara H, Nishii H, Komiyama T, et al. [Diffusely increased uptake in the skull in normal bone scans]. Kaku Igaku. 1992; 29:599–605.
7. Jacobsson H, Haverling M. Hyperostosis cranii. Radiography and scintigraphy compared.Acta Radiol. 1988; 29:223–226.
crossref
8. Ceylan E, Caner B. Evolution of hyperostosis frontalis interna butterfly sign demonstrated by bone scan. Clin Nucl Med. 2003; 28:78–79.
crossref
9. Novetsky GJ, Berlin L. Bone scintigraphy in hyperostosis frontalis interna. Clin Nucl Med. 1982; 7:265–266.
crossref
10. Harbert J, Desai R. Small calvarial bone scan foci–normal variations. J Nucl Med. 1985; 26:1144–1148.

Fig. 1.
A 48-year-old female with nasal septal epithelial-myoepithelial carcinoma. A. Anterior view of the bone scan shows discrete focal activity in the left superior lateral margin of the orbital rim (arrow). B, C. Axial and coronal fused positron emission tomography-computed tomography images demonstrate no corresponding abnormal uptake in the left superior lateral margin of the orbital rim.
jksr-80-81f1.tif
Fig. 2.
A 32-year-old male with urinary bladder cancer. A. Anterior view of the bone scan shows discrete focal activity in the superior lateral margin of the orbital rim (arrow). B. The bone scan performed at the 2-year follow up demonstrates no remarkable change over time (arrowhead).
jksr-80-81f2.tif
Table 1.
Characteristics of Patients and Patterns of Orbital Rim Uptake in Bone Scans
Case No. e Age/ Gender Underlying Disease Uptake Side Location Size Comparison Imaging Time Interval Clinical Diagnosis
No. 1 Gender M/32 Urinary bladder cancer Right Superior lateral < 1/4 Imaging Bone scan Interval 26 months Diagnosis NS
2 M/69 Prostate cancer Right Superior lateral < 1/4 PET/CT 13 months NS
3 M/73 Renal cancer Left Superior lateral < 1/4 PET/CT 5 months NS
3 4 M/73 M/47 Renal cancer Ankylosing spondylitis Left Right Superior lateral Superior lateral < 1/4 < 1/4 PET/CT CT 5 months 3 months NS NS
5 M/61 Renal cancer Left Lateral < 1/4 PET/CT 5 months NS
6 F/68 Trauma Left Superior medial < 1/4 CT 6 months NS
7 M/75 Prostate cancer Right Inferior lateral < 1/4 PET/CT 14 months NS
8 M/89 Prostate cancer Right Inferior lateral < 1/4 Bone scan 12 months NS
9 M/39 Trauma Right Lateral < 1/4 CT 1 month NS
10 F/50 Breast cancer Left Inferior medial < 1/4 Bone scan 7 months NS
11 F/47 Breast cancer Right Superior lateral < 1/4 PET/CT 2 months NS
12 F/48 Nasal septal cancer Left Superior lateral < 1/4 PET/CT 1 day NS
13 F/53 Breast cancer Right Inferior lateral < 1/4 PET/CT 7 months NS

NS = nonspecific, PET/CT =positron emission tomography-computed tomography

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