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Yoo and Kwon: New Potential Therapies for Chronic Hepatitis B
Special Review
Diagnosis and Treatment of Chronic Hepatitis B: How Far Have We Come?

The Korean Journal of Gastroenterology 2019; 74(5): 267-273.

Published online: 27 November 2019

DOI: https://doi.org/10.4166/kjg.2019.74.5.267

New Potential Therapies for Chronic Hepatitis B

Sun Hong Yoo, Jung Hyun Kwon

Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.

Correspondence to: Jung Hyun Kwon, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 56 Dongsu-ro, Bupyeong-gu, Incheon 21431, Korea. Tel: +82-32-280-5886, Fax: +82-32-280-5023, doctorkwon@catholic.ac.kr

Received 12 October 2019       Revised 23 October 2019       Accepted 25 October 2019

Copyright © 2019. Korean Society of Gastroenterology

Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A HBV infection is a dynamic disease and long-term liver inflammation contributes to the development of liver cirrhosis and hepatocellular carcinoma. Currently available nucleos(t)ide analogues and pegylated interferon are effective in inhibiting HBV replication but rarely achieve HBsAg clearance. The present article introduces a new definition of HBV cure and several emerging therapies for HBV cure, including direct acting antivirals and immune modulatory antivirals.

Keywords: Hepatitis B virus, Therapeutics

Figures and Tables

Fig. 1

HBV replication cycle and targets for new treatment. HBV, hepatitis B virus; cccDNA, covalently closed circular DNA; RNA, ribonucleic acid; siRNAs, small interfering RNAs.

kjg-74-267-g001
Table 1

Definitions of HBV Cure

kjg-74-267-i001

HBV, hepatitis B virus; HBsAg, hepatitis B surface antigen; Anti-HBs, antibody to hepatitis B s antigen; HBeAg, hepatitis B e antigen; cccDNA, covalently closed circular DNA.

Table 2

Direct Acting Antiviral Agents for HBV in the Developmental Pipeline (Modified from Lee and Banini9, with permission from Curr Treat Options Gastroenterol)

kjg-74-267-i002

HBV, hepatitis B virus; FDA, Food and Drug Administration; mRNA, messenger ribonucleic acid; TALEN, transcription activator-like endonucleases; IND, investigational new drug; HBsAg, hepatitis B surface antigen.

Table 3

Indirect Acting Antiviral Agents for HBV in the Developmental Pipeline (Modified from Lee and Banini9, with permission from Curr Treat Options Gastroenterol)

kjg-74-267-i003

HBV, hepatitis B virus; PD-1, programmed death-1.

Notes

Financial support None.

Conflict of interest None.

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ORCID iDs

Jung Hyun Kwon
https://orcid.org/0000-0002-5484-5864

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