A case of hair dye-induced contact anaphylaxis

Soo Myoung Shin; Yeonhee Lee; Hongran Moon; Sang-A Kim; Ji Hyun Oh; Sujie Chung; Ji Soo Shim; Hye-Ryun Kang

doi:10.4168/aard.2019.7.4.218

Journal List > Allergy Asthma Respir Dis > v.7(4) > 1138014

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Shin, Lee, Moon, Kim, Oh, Chung, Shim, and Kang: A case of hair dye-induced contact anaphylaxis

Case Report

Allergy Asthma Respir Dis 2019;7(4):218-221.

Published online: 12 October 2019

DOI: https://doi.org/10.4168/aard.2019.7.4.218

A case of hair dye-induced contact anaphylaxis

Soo Myoung Shin¹, Yeonhee Lee¹, Hongran Moon¹, Sang-A Kim¹, Ji Hyun Oh^1,², Sujie Chung¹, Ji Soo Shim^1,², Hye-Ryun Kang^1,²

^¹Department of Internal Medicine, Seoul National University Hospital, Seoul Korea

^²Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul Korea

Correspondence to: Hye-Ryun Kang https://orcid.org/0000-0002-2317-4201 Department of Internal Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Korea Tel: +82-2-2072-0820, Fax: +82-2-2742-3291, E-mail: helenmed@snu.ac.kr

Received 10 June 2018 Revised 7 August 2018 Accepted 8 August 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Anaphylaxis is a sudden-onset life-threatening systemic hypersensitivity reaction. Allergens, such as foods, stinging insect venoms, and drugs, are the globally important causative factors for anaphylaxis. Para-phenylenediamine (PPD), an aromatic amine, is a well-known hair dye component that can act as a skin irritant and/or a skin sensitizer. As an allergen, PPD can induce various reactions; the most common being contact dermatitis, a delayed-type hypersensitivity reaction. Anaphylaxis or other immediate hypersensitivity reactions by hair dye contact is extremely rare, with only a few cases reported worldwide. Here, we report a case of a 63-year-old female who presented to the Emergency Department with dyspnea, rash, vomiting, and diarrhea within minutes after using a hair dye product containing PPD. Her past medical history includes urticaria of unknown cause. Her total IgE antibody level was increased to 630 kU/L. Skin prick and patch tests with the hair dye she applied at the time of anaphylaxis demonstrated an immediate reaction. An additional patch test with 25 common contact allergens showed positive reaction to PPD. This is the first case report of hair dye-induced contact anaphylaxis presenting sensitization to PPD in Korea.

Keywords: Anaphylaxis, Hair dyes, Para-phenylenediamine

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Table 1.

Hair dye ingredients used in the subject of the presented case

Previously used hair dye ingredients	Newly used hair dye ingredients
p-phenylenediamine	Colorant
m-aminophenol	peg-2 oleamine
p-aminophenol	water
p-amino-o-cresol	peg-4 rapeseedamide, alcohol denat (alcohol)
p-nitro-o-phenylenediamine resorcinol	propylene glycol oleic acid
	ethanolamine hydrolyzed vegetable protein
	limnanthes alba (meadowfoam) seed oil
	tetrasodium glutamate diacetate sodium metabisulfite
	sodium erythorbate
	p-phenylenediamine
	4-chlororesorcinol
	2-amino-4-hydroxyethylaminoanisole sulfate
	N,N-bis (2-hydroxyethyl)-p-phenylenediamine sulfate
	4-amino-2-hydroxytoluenene
	m-aminophenol
	Color developer
	water
	hydrogen peroxide
	cetyl alcohol
	cetearyl alcohol
	laureth-3
	ceteareth-20
	oxyquinoline sulfate phosphoric acid

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