Journal List > Allergy Asthma Respir Dis > v.7(4) > 1138014

Allergy Asthma Respir Dis. 2019 Oct;7(4):218-221. Korean.
Published online Oct 30, 2019.
© 2019 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
A case of hair dye-induced contact anaphylaxis
Soo Myoung Shin,1 Yeonhee Lee,1 Hongran Moon,1 Sang-A Kim,1 Ji Hyun Oh,1,2 Sujie Chung,1 Ji Soo Shim,1,2 and Hye-Ryun Kang1,2
1Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
2Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.

Correspondence to: Hye-Ryun Kang. Department of Internal Medicine, Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Korea. Tel: +82-2-2072-0820, Fax: +82-2-2742-3291, Email:
Received Jun 10, 2018; Revised Aug 07, 2018; Accepted Aug 08, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (


Anaphylaxis is a sudden-onset life-threatening systemic hypersensitivity reaction. Allergens, such as foods, stinging insect venoms, and drugs, are the globally important causative factors for anaphylaxis. Para-phenylenediamine (PPD), an aromatic amine, is a well-known hair dye component that can act as a skin irritant and/or a skin sensitizer. As an allergen, PPD can induce various reactions; the most common being contact dermatitis, a delayed-type hypersensitivity reaction. Anaphylaxis or other immediate hypersensitivity reactions by hair dye contact is extremely rare, with only a few cases reported worldwide. Here, we report a case of a 63-year-old female who presented to the Emergency Department with dyspnea, rash, vomiting, and diarrhea within minutes after using a hair dye product containing PPD. Her past medical history includes urticaria of unknown cause. Her total IgE antibody level was increased to 630 kU/L. Skin prick and patch tests with the hair dye she applied at the time of anaphylaxis demonstrated an immediate reaction. An additional patch test with 25 common contact allergens showed positive reaction to PPD. This is the first case report of hair dye-induced contact anaphylaxis presenting sensitization to PPD in Korea.

Keywords: Anaphylaxis; Hair dyes; Para-phenylenediamine


Table 1
Hair dye ingredients used in the subject of the presented case
Click for larger imageClick for full tableDownload as Excel file

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