Abstract
Purpose
Materials and Methods
Results
ACKNOWLEDGEMENTS
Notes
AUTHOR CONTRIBUTIONS:
Conceptualization: Sung Soo Ahn and Sang-Won Lee.
Data curation: Sung Soo Ahn, Seung Min Jung, and Sang-Won Lee.
Formal analysis: Sung Soo Ahn and Sang-Won Lee.
Funding acquisition: Sang-Won Lee.
Investigation: Sung Soo Ahn and Sang-Won Lee.
Methodology: Sung Soo Ahn, Seung Min Jung, and Sang-Won Lee.
Project administration: Sung Soo Ahn and Sang-Won Lee.
Resources: All authors.
Software: Sung Soo Ahn and Sang-Won Lee.
Supervision: Jason Jungsik Song and Yong-Beom Park.
Validation: Jason Jungsik Song, Yong-Beom Park, and Sang-Won Lee.
Visualization: Sung Soo Ahn and Sang-Won Lee.
Writing—original draft: Sung Soo Ahn and Sang-Won Lee.
Writing—review & editing: All authors.
References
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SUPPLEMENTARY MATERIALS
Supplementary Table 1
Supplementary Table 2
Fig. 1
Receiver operator characteristics curve analysis of controlling nutritional status score at diagnosis for predicting occurrence of (A) all-cause mortality, (B) relapse, and (C) end-stage renal disease (ESRD). CI, confidence interval.
![ymj-60-1164-g001](/upload/SynapseXML/0069ymj/thumb/ymj-60-1164-g001.jpg)
Fig. 2
Kaplan-Meier analysis of controlling nutritional status (CONUT) score at diagnosis for predicting occurrence of all-cause mortality and end-stage renal disease (ESRD) during follow-up. (A) All-cause mortality and (B) ESRD.
![ymj-60-1164-g002](/upload/SynapseXML/0069ymj/thumb/ymj-60-1164-g002.jpg)
Table 1
Comparison of Variables between AAV Patients with Low and High CONUT Scores at Diagnosis
![ymj-60-1164-i001](/upload/SynapseXML/0069ymj/thumb/ymj-60-1164-i001.jpg)
AAV, ANCA-associated vasculitis; CONUT, controlling nutritional status; MPA, microscopic polyangiitis; GPA, granulomatosis with polyangiitis; EGPA, eosinophilic granulomatosis with polyangiitis; ANCA, antineutrophil cytoplasmic antibody; MPO, myeloperoxidase; P, perinuclear; PR3, proteinase 3; C, cytoplasmic; BVAS, Birmingham vasculitis activity score; FFS, five-factor score; INR, international normalized ratio; BUN, blood urea nitrogen; AST, aspartate transaminase; ALT, alanine transaminase; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein.
Values are expressed as mean±standard deviation or number (%) unless otherwise indicated.
Table 2
Comparison of Clinical Outcomes, Comorbidities, and Immunosuppressive Therapies during Follow-Up between AAV Patients with Low and High CONUT Scores at Diagnosis
![ymj-60-1164-i002](/upload/SynapseXML/0069ymj/thumb/ymj-60-1164-i002.jpg)
Table 3
Predictors of All-Cause Mortality during Follow-Up in AAV Patients
![ymj-60-1164-i003](/upload/SynapseXML/0069ymj/thumb/ymj-60-1164-i003.jpg)
AAV, ANCA-associated vasculitis; HR, hazard ratio; CI, confidence interval; ANCA, antineutrophil cytoplasmic antibody; BVAS, Birmingham vasculitis activity score; FFS, five-factor score; BUN, blood urea nitrogen; AST, aspartate transaminase; ALT, alanine transaminase; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; CONUT, controlling nutritional status.
*Due to multicollinearity between serum albumin and CONUT score, serum albumin was excluded from multivariate Cox hazards model analysis despite a statistically significant association found in univariate analysis.
Table 4
Predictors of ESRD during Follow-Up in AAV Patients
![ymj-60-1164-i004](/upload/SynapseXML/0069ymj/thumb/ymj-60-1164-i004.jpg)
ESRD, end-stage renal disease; AAV, ANCA-associated vasculitis; HR, hazard ratio; CI, confidence interval; ANCA, antineutrophil cytoplasmic antibody; BVAS, Birmingham vasculitis activity score; FFS, five-factor score; BUN, blood urea nitrogen; AST, aspartate transaminase; ALT, alanine transaminase; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; CONUT, controlling nutritional status.
*Although lymphocyte count is one of the criteria of CONUT scoring system, it was included in multivariate analysis since no multicollinearity was observed between lymphocyte count and the score.