Localized cutaneous argyria is a rare condition in which blue-grey pigmentation results from impregnation of the skin by silver particles1. Localized cutaneous argyria occurs when skin directly absorbs silver particles and presents as an elliptical blue-gray macule or papule. This clinical manifestation is often confused with the angiomas, blue nevi, dysplastic nevi, melanoma in situ and malignant melanoma because of the overlap with melanocytic lesions2. Therefore, radiographic and histologic confirmations are recommended for accurate diagnosis. Analysis of the tissue with scanning electron microscopy and energy dispersive x-ray spectroscopy (SEM-EDS) identified silver and provided confirmatory evidence of localized cutaneous argyria2. The case of localized cutaneous argyria resulted from the wearing of silver earrings has been seldom reported. The current report shows the localized cutaneous argyria in earlobe, may be caused by silver earrings.

A 21-year-old woman presented with an asymptomatic solitary bluish macule on posterior aspect of right earlobe. For 10 years, the patient had worn earrings on his right earlobe. Then the color of her posterior earlobe has been gradually changed to blue, and thereafter a 0.7×0.7 cm bluish macule was observed on the posterior aspect of right earlobe (Fig. 1). The clinical impression was blue nevus. A punch biopsy was performed. Sections with hematoxylin and eosin staining revealed that the specimen was normal epidermis and the brown pigmentation was resulted from deposition of foreign substance on the dermal elastic and collagen fibers, and also basement membrane of eccrine sweat glands (Fig. 2A, B). A definitive diagnosis was rendered after SEM-EDS analysis of the tissue demonstrated the presence of silver (Fig. 2C, D). We received the patient's consent form about publishing all photographic materials.

Argyria is a skin discoloration associated with silver absorption. The incidence of argyria was highest in 19th and 20th centuries due to the frequent ingestion or topical applications of silver-containing compounds2. Today, localized cutaneous argyria has become a relatively rare disease due to a significant reduction in the use of silver-containing medications2. However, heavy metals, including silver, can be introduced into the skin inadvertently through occupational exposure, acupuncture, earrings, topical silver medication, or trauma, etc.

Localized cutaneous argyria caused by direct contact of the silver-containing compounds is rarely reported in Korean literatures. To best of our knowledge, total of three cases have been reported. Kwon et al.3 have reported two cases of localized cutaneous argyria in hands caused by chemical experiment called silver mirror reaction. Park et al.4 have reported one case of localized cutaneous argyria caused by acupuncture.

Localized cutaneous argyria is caused by direct external contact of silver. The most commonly affected areas are the hands, eyes, and the mucosa. Silver is suggested to be deposited in the dermis in a chemically stable and inactive form. It is also believed that argyria occurs through the eccrine sweat ducts because the metal is most concentrated around the secretion site of the sweat glands. However, clear mechanism of the penetration is not known5. Argyria represents clinically asymptomatic blue-gray macule or papule with local discoloration similar to melanocyte proliferation6. Histologically, the argyria exhibits normal epidermis and multicellular brown streaks and granules. Particularly, in high magnification, those streaks and granules shows interstitial and periadnexal distributions around the secretory coils of the sweat glands or along the elastic fibers of the dermis.

Diagnosis of localized cutaneous argyria is usually obvious due to the location of lesion correlated with specific history and clinical manifestation. The radiography is also recommended for diagnosis by confirming the presence of metallic particles. However, the absence of radiographic evidence does not rule out the diagnosis of disease, since particles are often too fine or widely dispersed to be visible on radiographs. When there is no radiographic evidence, biopsy is recommended to rule out angiomas, blue nevi, dysplastic nevi melanoma in situ and malignant melanoma. Analysis of the tissue with SEM-EDS identified silver and provided confirmatory evidence of localized cutaneous argyria2. Microanalytical techniques, such as SEMEDS, can be used to identify chemical elements within a biopsy specimen and establish a definitive diagnosis. SEM exposes a tissue sample to electrons altering the elements at the atomic level and resulting in emission of x-rays, which are measured by EDS. Because individual elements have characteristic emission patterns, the elements are easily identified. SEM-EDS analysis is performed by specialty laboratories and produces accurate results in a timely manner2. Once the diagnosis of localized cutaneous argyria has been established, no additional treatment is necessary except for cosmetic reasons. If the pigmentation is cosmetically unacceptable, 5% hydroquinone, Q-switched 1064-nm neodymium-doped yttrium-aluminium-garnet (Nd: YAG) laser or surgical excision has been suggested7.

We report the case of earring-induced localized cutaneous argyria which was mimicking blue nevus. We performed biopsy for the lesion and prove the localized cutaneous argyria using SEM-EDS techniques. In this manuscript, our patient had worn silver earrings on both earlobes, but argyria occurred only one earlobe. This implies that argyria does not just result from wearing silver earrings. And it is also believed that argyria can be caused by repeated trauma when hanging or pulling the silver earrings. However, further investigation is required. When the clinical feature is a blue nevus without histopathologic evidence of melanocytic proliferation, localized cutaneous argyria should be considered in the differential diagnosis of patients who had been wearing earrings. We report this case with review of the literature.