Percutaneous biopsy is the most frequent interventional radiographic procedure. Its increased use is relatedto new imaging techniques facilitating needle placement, greater safety of fine needle and advances in cytology.CT because of its characteristic high spatial and density resolution, permits the accurate localization of anylesion in the body. Because of the ability of CT scans to precisely localize lesions and biopsy needle, along withthe delineation of adjacent structure, it is widely used in percutaneous biopsy. Sixty-six cases of CT-guidedpercutaneous fine-needle biopsy were performed in order to diagnose suspected malignant or infectious disease(49malignant and 17 infectious) over a 7-month period(June 1984 through Dec. 1984). Most of these procedures wereperformed on, but not limited to, the lung(21), liver(20), and pancreas(7). The spine and nasopharynx could alsosafely be biopsied. 4 cases of hepatic abscesses were successfully drained following insertion of drainingcatheter under the CT-guidance. The overall accuracy of both suspected malignant and infectious disease was 82%.Complication rate was low as 6%(4 cases only in thorax). Neither complication require any further intervention.Three were self-limited pneumothoraces and one was minimal hemorrhage around the needle tract.