Effect of 3% Diquafosol Tetrasodium on Tear Film Stability after Laser-assisted in situ Keratomileusis

Chang Hwan Kim; San Seong; Jong Ku Kim; Jae Ho Choi; Chul Myong Choe; Tae Hoon Choi; Sekyung Kim

doi:10.3341/jkos.2019.60.10.915

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Kim, Seong, Kim, Choi, Choe, Choi, and Kim: Effect of 3% Diquafosol Tetrasodium on Tear Film Stability after Laser-assisted in situ Keratomileusis

Original Article

Journal of the Korean Ophthalmological Society 2019; 60(10): 915-921.

Published online: 21 October 2019

DOI: https://doi.org/10.3341/jkos.2019.60.10.915

Effect of 3% Diquafosol Tetrasodium on Tear Film Stability after Laser-assisted in situ Keratomileusis

Chang Hwan Kim, MD¹, San Seong, MD¹, Jong Ku Kim, MD², Jae Ho Choi, MD², Chul Myong Choe, MD¹, Tae Hoon Choi, MD¹, Sekyung Kim, MD¹

¹Nune Eye Hospital, Seoul, Korea.

²Nune Eye Hospital, Daegu, Korea.

Address reprint requests to Se Kyung Kim, MD. Nune Eye Hospital, #404 Seolleung-ro, Gangnam-gu, Seoul 06198, Korea. Tel: 82-2-2086-7792, Fax: 82-2-2086-7710, sekyungkim@naver.com

Received 4 April 2019 Revised 27 May 2019 Accepted 24 September 2019

The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To evaluate the efficacy of 3% diquafosol tetrasodium (DQ) after laser-assisted in-situ keratomileusis (LASIK).

Methods

This prospective randomized study included 150 eyes in 75 patients who were scheduled for LASIK. The patients in the 3% diquafosol tetrasodium (DQ) group (37 patients, 74 eyes) were instructed to apply one drop of DQ, six times daily post-op, while the patients in the 0.3% sodium hyaluronate (HA) group (38 patients, 76 eyes) were instructed to apply one drop of HA, six times daily post-op. A Schirmer test, tear film break-up time (BUT), corneal and conjunctival fluorescein staining score (FLSS), and ocular surface disease index (OSDI) were evaluated pre-op and at 1, 4, and 12 weeks post-op while the tear osmolarity was evaluated pre-op and at 4 and 12 weeks post-op.

Results

There was no significant difference between the two groups regarding Schirmer test results or tear osmolarity and conjunctival FLSS. The BUT was significantly higher in the DQ group at 1 week and 12 weeks post-op. The corneal FLSS was significantly lower in the DQ group at 1 week, 4 weeks and 12 weeks post-op. The OSDI was significantly lower in the DQ group at 1 week post-op.

Conclusions

Use of 3% diquafosol tetrasodium after surgery improved ocular dryness and increased the tear film stability.

Keywords: Diquafosol, Dry eyes, Laser-assisted in-situ keratomileusis, Tear film stability

Figures and Tables

Figure 1

Cornea and conjunctival fluorescein stain grading. The National Eye Institute/Industry grading system for grading fluorescein staining divides the corneal and conjunctival surfaces to help measure fluorescein uptake. A standardized grading system of 0 to 3 is used for each of the five areas on each cornea and each of the six areas on each conjunctiva.

Figure 2

Changes in Tear film break-up time (A), corneal fluorescein staining score (B), conjunctival fluorescein staining score (C), Schirmer test (D), tear osmolarity (E), and ocular surface disease index (F) in the 3% diquafosol tetrasodium and 0.3% sodium hyaluronate group before and after laser-assisted in-situ keratomileusis. ‘DQ’ is 3% diquafosol tetrasodium group, ‘HA’ is 0.3% sodium hyaluronate group. LASIK = laser-assisted in-situ keratomileusis. ^*Repeat measures analysis of variance test, p < 0.05 between 3% diquafosol tetrasodium and 0.3% sodium hyaluronate group.

Table 1

Patient demographics and other baseline characteristics

Values are presented as mean ± standard deviation or number (%).

FL = fluorescein.

^*t-test.

Notes

^{Conflicts of Interest} The authors have no conflicts to disclose.

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