Journal List > Korean J Gastroenterol > v.74(3) > 1134170

Heo: Hepatitis E Virus: Epidemiology, Diagnosis, and Management

Abstract

The HEV is a known cause of water-borne outbreaks of acute non-A non-B hepatitis in developing countries, which affects young people and may result in high mortality in pregnant women. In recent decades, however, HEV genotypes 3 and 4 have been known as a cause of sporadic zoonotic infections in older males from swine HEV worldwide. Most acute HEV infections are self-limited. On the other hand, in immunosuppressed patients, including solid organ transplant recipients, chronic HEV infections may exist and progress to liver cirrhosis or decompensation. Therefore, physicians need to recognize HEV as a major pathogen for acute and chronic hepatitis of unknown causes and investigate this disease.

Figures and Tables

Fig. 1

Transmission route of hepatitis E virus genotype 1 and 2 (A), and genotype 3 and 4 (B).

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Table 1

Epidemiological and Clinical Features of Hepatitis E Virus Infection according to Genotype

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HEV-1, hepatitis E virus genotype 1; HEV-2, hepatitis E virus genotype 2; HEV-3, hepatitis E virus, genotype 3; HEV-4, hepatitis E virus genotype 4.

Notes

Financial support None.

Conflict of interest None.

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Nae-Yun Heo
https://orcid.org/0000-0001-6571-8935

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