Percutaneous alcohol injection (PAI) is a new sclerosing method for treatment of diseases such as cyst, malignant tumor and benign neoplasm, Percutaneous alcohol injection of 26 cases(adenomatous goiter 23 cases, follicular adenoma 2 cases & recurrent papillary carcinoma 1 case) of thyroid nodules were done with 23-G needle under the guidance of ultrasonography. After then, we followed up thyroid function test, ultrasonographical sizeand volume of nodules, cytologic examination and complications of treatment. The results were as follows; 1. With0.5-1cc alcohol injection, the mean volumes of thyroid nodules were reduced after PAI to 59% (N=26) at 1 month,and to 33%(N=14,cases of additonal PAI) at 6 months, of the base line volume (100%) before PAI. 2. There were nosignificant changes at 1 and 6 months follow-up of TFT after PAI in all cases as compared with base line studies.3. In conclusion, ultrasonic guided PAI for thyroid nodule is simple, useful and cost-effective method, and recommendable in cases of mixed and solid nodules resistant to medical treatment, refusal of surgery because of cosmetic problem and recurrent malignant tumors.