Endoscopic esophageal sclerotherapy(EES) has been widely accepted for management of bleeding esophageal varices. Authors reviewed CT findings of mediastinal and pleural changes before and after EES for the evaluationof the effect and complication. The mediastinal and pleural changes within 3 days(n=20) after EES were esophageal thickening (80%), esophageal lamination(40%), paraesophageal gas collection(35%), paraesophageal mediastinal effusion(80%), and pleural effusion(50%). After 2 months(n=5), all these findings were disappeared, except formild residual esophageal thickening. The knowledge of CT findings after EES appeared essential for CT scan images performed in the patients suspected of having severe postprocedural complications and for the differential diagnosis.