Intra-arterial Chemotherapy(ICA) was performed to the 34 patients with nonmetastatic osteosarcoma using Cisplatin and surgery was done in 25 cases out of 34. We analysed the therapeutic effect of IAC in the view oflocal control rate and distant metastasis of two and half years. Local control rate was 94% on the base of theradiologic studies including simple X-ray, angiography and CT. No viable cells were observed in 50% of the caseson the pathologic examination of the surgical specimens. Distant metastasis developed in 14 cases(41%), mainly inthe lung. No significant complications occurred except each case of acute renal failure, congestive heart failureand peripheral embolism, which were improved by proper management. IAC is one of the most effective methods incontrolling the regionally confined osteosarcoma, but it may be incorperated with other adjuvant protocols todecrease the chance of delayed metastasis.