Percutaneous cholecystostomy is regarded as a new method of treatment in patients with acute cholecystitis,especially patients with empyema who are considered unsuitable for cholecystectomy. In recent 2 years, authorsperformed percutaneous cholecystostomy for drainage purpose in 10 patients with poor surgical candidate. Under theguidance of real time ultrasound or fluoroscope, transhepatic access route for gallbladder intervention werechosen in all cases. Successful decompression were obtained in 7 cases(70%; 6 patients with acute cholecystitishad decompression of gallbladder and 1 patient with common bile duct stone had biliary decompression. In thereepatient with cholecystitis, who had severe liver cirrhosis(N=1) or sepsis(N=2) as underlying condition,gallbladdeer drainage was not effective. Neither bile peritonitis nor hypotension occurred in any of these 10cases. Percutaneous cholecystostomy has proved to be safe and effective treatment for patients with gallbladderdisease who are poor surgical candidate.