Two patients with skeletal metastasis from hepatocellular carcinoma(HCC) treated with internal radiation arepresented. An oily contrast medium injected into the hepatic artery accumulates in the hepatic tumor tissue andremains there for long periods: therfore, an oily contrast tagged with radioactive iodine could intensifytherapeutic effect on tumors. I-131 was tagged onto Lipiodol, an idodized oil, and injected into the arteriessupplying the tumors of skeletal metastasis and hepatocellular carcinoma delivering high internal radiation toboth primary and secondary lesions. At 6-month follow-up period, tumor has decreased in size and patients arealive and pain free.