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Cho, Kim, Lee, and Hong: Metastasis of Hepatocellular Carcinoma to Pituitary Adenoma: A Case Report
Case Report

J Korean Soc Radiol 2019;80(1):153-156.

Published online: 20 January 2019

DOI: https://doi.org/10.3348/jksr.2019.80.1.153

Metastasis of Hepatocellular Carcinoma to Pituitary Adenoma: A Case Report

Yong Soo Cho, MD1, ∗, Chong Gue Kim, MD2, Mi Ja Lee, MD3, Yeong Sang Hong, MD1

1Department of Radiology, Chosun University Hospital, Chosun University Colleg of Medicine, Gwangju, Korea

2Department of Neurosurgery, Chosun University Hospital, Chosun University Colleg of Medicine, Gwangju, Korea

3Department of Pathology, Chosun University Hospital, Chosun University Colleg of Medicine, Gwangju, Korea

∗Corresponding author Yong Soo Cho, MD Department of Radiology, Chosun University Hospital, 365 Pilmun-daero, Dong-gu, Gwangju 61453, Korea. Tel 82-62-220-3543 Fax 82-62-228-9061 E-mail waveys1@hanmail.net

Received 13 April 2018       Revised 31 May 2018       Accepted 25 July 2018

Copyright © 2019 The Korean Society of Radiology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Metastasis to the pituitary gland is unusual, and metastasis to pituitary adenoma is extremely rare. We report here on a case of hepatocellular carcinoma metastasizing to a pituitary adenoma with MRI findings.

References

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Fig. 1.
A 72-year-old man with HCC metastasis to pituitary adenoma presenting with oculomotor nerve palsy. A, B. Initial sella MRI (A, coronal T2-weighted; B, coronal contrast-enhanced T1-weighted image 30 second after administration of gadolinium) demonstrate a tumor (2.6 × 1.1 cm) located in pituitary fossa and left cavernous sinus. The tumor is revealed as slight hyper-intensity compared with gray matter on T2-weighted image and relatively homogeneous enhancement after administration of gadolinium. C, D. Two years later, sella MRI (C, coronal T2-weighted; D, coronal contrast-enhanced T1-weighted image 30 second after administration of gadolinium) show increase in size of pituitary tumor (2.8 × 1.3 cm). On T2-weighted image (C), distinct hypointense nodular area is seen within pre-existing sellar tumor showing strong enhancement after admis-tration of gadolinium on T1-weighted image (D). E, F. Histological tumor specimens (× 200). (E) Hematoxylin and eosin staining of the pituitary tumor shows metastatic HCC (#) to pituitary adenoma (∗). (F) Hepatocyte specific antigen immunohistochemical result shows reactive in metastatic HCC (#). HCC = hepatocellular carcinoma
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