Abstract
We report an ectopic mediastinal parathyroid adenoma in a patient with chronic kidney disease who presented with refractory hypercalcemia. Technetium-99m-sestamibi scintigraphy is avaluable imaging technique for the detection of an ectopic parathyroid adenoma in the medi-astinum. The combination of intense contrast enhancement and the identification of a polar vessel on a computed tomography scan will ensure that a radiologist can differentiate a parathyroid adenoma from other pathologies in the mediastinum. By virtue of the advancement of imaging modalities, localization of an ectopic mediastinal parathyroid adenoma prior to surgery is possible and unnecessary neck exploration is avoidable.
References
1. Eslamy HK, Ziessman HA. Parathyroid scintigraphy in patients with primary hyperparathyroidism: 99mTc sestamibi SPECT and SPECT/CT.Rad/iiograph/iics. 2008; 28:1461–1476.
2. Cozzolino M. CKD-MBD KDIGO guidelines: how difficult is reaching the ‘target'? Clinical Kidney J. 2018; 11:70–72.
3. Yuen NK, Ananthakrishnan S, Campbell MJ. Hyperparathyroidism of renal disease.Perm J. 2016; 20:78–83.
4. Lunn MR, Muñoz Mendoza J, Pasche LJ, Norton JA, Ayco AL, Chertow GM. Hyperparathyroidism with hypercalcaemia in chronic kidney disease: primary or tertiary? NDT Plus. 2010; 3:366–371.
5. Hu J, Ngiam KY, Parameswaran R. Mediastinal parathyroid adenomas and their surgical implications. Ann R Coll Surg Engl. 2015; 97:259–261.
6. Gordon J, Manley NR. Mechanisms of thymus organogenesis and morphogenesis. Development. 2011; 138:3865–3878.
7. Roy M, Mazeh H, Chen H, Sippel RS. Incidence and localization of ectopic parathyroid adenomas in previously unexplored patients. World J Surg. 2013; 37:102–106.
8. Lane MJ, Desser TS, Weigel RJ, Jeffrey RB Jr. Use of color and power Doppler sonography to identify feeding arteries associated with parathyroid adenomas.AJR Am J Roentgenol. 1998; 171:819–823.
9. Rodgers SE, Hunter GJ, Hamberg LM, Schellingerhout D, Doherty DB, Ayers GD, et al. Improved preoperative planning for directed parathyroidectomy with 4-dimensional computed tomography.Surgery. 2006; 140:932–940. ; discussion 940–941.