Research Areas and Trends in Articles on Pediatric and Adolescent Tuberculosis in Korea

Ho Yoon Lim; Jung Hyun Lee; Yu Jin Jung; Chi Eun Oh

doi:10.14776/piv.2019.26.2.89

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Lim, Lee, Jung, and Oh: Research Areas and Trends in Articles on Pediatric and Adolescent Tuberculosis in Korea

Original Article

Pediatr Infect Vaccine 2019;26(2):89-98.

Published online: 20 August 2019

DOI: https://doi.org/10.14776/piv.2019.26.2.89

Research Areas and Trends in Articles on Pediatric and Adolescent Tuberculosis in Korea

Ho Yoon Lim¹, Jung Hyun Lee^1,², Yu Jin Jung^1,², Chi Eun Oh^1,^2,

¹Department of Pediatrics, Kosin University Gospel Hospital, Busan, the Republic of Korea

²Department of Pediatrics, Kosin University College of Medicine, Busan, the Republic of Korea

Correspondence to Chi Eun Oh Department of Pediatrics, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 49267, the Republic of Korea. E-mail: chieunoh@kosin.ac.kr

Received 5 April 2019 Revised 30 April 2019 Accepted 16 May 2019

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

Despite the decline in tuberculosis (TB) incidence and mortality rates in the Republic of Korea through a national TB control program, TB remains one of the most critical infectious diseases in Korean children. We investigated the trends and research areas of published articles on TB in Korean children and adolescents.

Methods

In 6 Korean and overseas databases, we searched titles and abstracts including “tuberculo∗” or “TB,” “child∗” or “adolescen∗” or “neonat∗” or “infant∗” or “pediatric∗,” and “korea∗.” The publication type, publication year, research areas, journal title, and research subjects were analyzed.

Results

Out of the 257 searched documents, 120 papers were included in the analysis. Of these, 82 were original articles (68.3%), 33 case reports (27.5%), 4 review articles (3.3%), and 1 guideline (0.8%). In the original articles, the most common subject of studies was the clinical characteristics of patients with TB (36.6%), followed by diagnostics (29.3%), contact investigations (9.8%), epidemiology (6.1%), treatment (4.9%), vaccine (3.6%), latent TB infection (3.6%), complications (3.6%), and surveys on perception of TB (2.4%). From 1962, 4 articles were published in the 1960s, 10 articles in the 1970s, 11 articles in the 1980s, 22 articles in the 1990s, 26 articles in the 2000s, and 47 articles since 2010.

Conclusions

The amount of research on TB in Korean children has increased over the past 5 decades; however, it has mainly focused on the clinical characteristics and diagnostics. Research in different areas, such as treatment and vaccine, is needed in the future.

Keywords: Tuberculosis, Research, Child, Adolescent, Republic of Korea

References

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Fig. 1.

Flow chart of article selection.

Fig. 2.

Number of articles regarding pediatric and adolescent tuberculosis in Korea by time period.

Fig. 3.

Number of articles regarding pediatric and adolescent tuberculosis in Korea by journals.

Table 1.

Research areas and subject details of 82 original articles

Research areas	Subject of articles	No. of related articles
Clinical characteristics	Pulmonary TB	8
	Miliary TB	6
	Tuberculous meningitis	6
	Childhood cancer patients	3
	Spinal TB	2
	Genitourinary TB	2
	Endobronchial TB	1
	Intracranial TB	1
	Fundus findings in TB	1
Diagnosis	IGRA	11
	Comparison of IGRA and TST	4
	Adenosine deaminase	2
	Bronchoscopy	2
	TST	2
	Bacteriologic examination	1
	Peripheral-blood-based PCR assay	1
	Mass miniature radiography	1
Contact investigation		8
Epidemiology	Drug-resistant TB	3
	Prevalence	1
	Molecular epidemiology	1
Treatment	Rifampin effects	2
	Plaster-of-paris jackets	1
	Effects of chemoprophylaxis	1
Complication	Spinal TB	2
	Growth change after knee joint TB	1
LTBI	Risk factors	2
	Relationship between asthma	1
Knowledge and attitudes toward TB		2

Abbreviations: TB, tuberculosis; IGRA, interferon-gamma release assay; TST, tuberculin skin test; PCR, polymerase chain reaction; LTBI, latent tuberculosis infection.

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