Journal List > J Korean Ophthalmol Soc > v.60(8) > 1130591

Park, Yoo, Kim, Cho, Seo, and Kim: Clinical Aspects of Infectious Keratitis in Western Gyeongsangnamdo, Republic of Korea



We investigated the regional characteristics and trends in causative agents, clinical features, and antibiotic susceptibility in infectious keratitis in western Gyeongnam province.


This retrospective chart review included 551 eyes of 551 patients with infectious keratitis, who were referred to our center from January 2004 to December 2017. The period of this study was divided into two terms of 7 years before and after 2011 to analyze the changes in causative organisms and antibiotic susceptibilities and to investigate the clinical features and regional characteristics in western Gyeongnam province.


The most common occupation among patients was farming; the mean time taken for initial treatment was 8.6 days. The culture positivity rate was 35.8%, the most commonly isolated microorganisms were Staphylococcus epidermidis (14.5%) for Gram-positive bacteria and Pseudomona aeruginosa (13.5%) for Gram-negative bacteria. The distribution of culture-positive organisms before and after 2011 did not show any significant difference, but the increase in resistance to second and third generation quinolones was significantly greater in Gram-positive bacteria after 2011. There was no significant difference in clinical characteristics before and after 2011, but the hospital stay duration and treatment needs were significantly reduced.


This was a large-scale study analyzing the clinical features of infectious keratitis in western Gyeognam province over a 14-year period. The results will help us understand the characteristics, microbiology, and community in infectious keratitis by analyzing patients referred to tertiary centers.

Figures and Tables

Table 1

Baseline characteristics and clinical aspects


Values are presented as number (%) or mean ± standard deviation (range).

Table 2

Cause of infectious keratitis


Values are presented as number (%).

*Percentage in trauma group.

Table 3

Demographics and clinical results before and after 2011


Values are presented as mean ± standard deviation or number (%).

D = diopter; BCVA = best corrected visual acuity; LogMAR = logarithm of minimal angle of resolution.

*Mann-Whitney U test; Fisher's exact test.

Table 4

Cultured isolates from corneal scrapes


Values are presented as number (%).

Table 5

Comparisons of cultured isolates before and after 2011


Values are presented as number (%).

Table 6

Antimicrobial resistance of Gram-positive isolates


*χ2-test; Fisher's exact test.

Table 7

Antimicrobial resistance of overall Gram-negative isolates


TMP/SMX = trimethoprim/sulfamethoxazole.

*χ2-test; Fisher's exact test.

Table 8

Surgical interventions in patients with infectious keratitis


Values are presented as number (%).

*χ2-test; Fisher's exact test.


Conflicts of Interest The authors have no conflicts to disclose.


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