Journal List > J Korean Ophthalmol Soc > v.60(8) > 1130589

Kim, Mun, Kim, Yang, Moon, and Chung: Short-term Clinical Outcomes of Small Incision Lenticule Extraction for Correction of Myopia Patients with Corneal Opacity



To evaluate the clinical outcomes of small incision lenticule extraction (SMILE) for the treatment of myopia with corneal opacity.


Thirteen eyes of 13 patients with corneal opacities who underwent SMILE were retrospectively studied. Uncorrected distance visual acuity, spherical equivalence, efficacy index, and safety index were noted at 3 months after the procedure. The density and area of the corneal opacities were measured and compared preoperatively and 3 months postoperatively.


All eyes had preoperative corneal opacities within the lenticule formation areas. The mean area and density of corneal opacities were 0.72 ± 0.33 mm2 and 52.46 ± 15.74, respectively. All procedures were uneventful and no intraoperative complications were observed. At 3 months after the procedure, the efficacy and safety indices were 1.01 ± 0.15, and 1.05 ± 0.10, respectively, and the mean densities and areas of corneal opacities were 46.85 ± 14.56 (p = 0.038) and 0.70 ± 0.36 mm2 (p = 0.776), respectively.


The SMILE procedure was effective and safe for the correction of myopic patients with corneal opacities.

Figures and Tables

Figure 1

Anterior segment photos of case No. 2, 3, 4, 5, 6, 7, 9, 10, 12. The corneal opacity of all eyes was within the lenticule formation area.

Figure 2

The preoperative, intraoperative, and postoperative corneal examinations in case No. 1. (A) The preoperative corneal opacity was noted by slit-lamp microscopy. (B) Corneal opacity was noted during lenticule scanning (red arrow). (C) The lenticule was separated successfully. (D) The preoperative anterior segment optical coherence tomography (AS-OCT) image. Thickening of epithelium and hyper-reflectivity of anterior stroma at corneal opacity lesion was noted. (E) The postoperative AS-OCT image. Thinning of the opacity lesion was noted.

Table 1

Patient demographics


CDVA = corrected distance visual acuity; M = male; F = female.

Table 2

The preoperative and postoperative mean density and mean area of corneal opacity


Values are presented as mean ± standard deviation.

*Paired t-test.


Conflicts of Interest The authors have no conflicts to disclose.


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