Prevention of Major Adverse Cardiovascular and Renal Outcomes with Sodium-Glucose Cotransporter 2 Inhibitors

Jun Hwa Hong

doi:10.4093/jkd.2019.20.2.87

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Hong: Prevention of Major Adverse Cardiovascular and Renal Outcomes with Sodium-Glucose Cotransporter 2 Inhibitors

Focused Issue

The Journal of Korean Diabetes 2019; 20(2): 87-91.

Published online: 30 June 2019

DOI: https://doi.org/10.4093/jkd.2019.20.2.87

Prevention of Major Adverse Cardiovascular and Renal Outcomes with Sodium-Glucose Cotransporter 2 Inhibitors

Jun Hwa Hong

Division of Endocrinology and Metabolism, Department of Internal Medicine, Eulji University Hospital, Daejeon, Korea.

Corresponding author: Jun Hwa Hong. Division of Endocrinology and Metabolism, Department of Internal Medicine, Eulji University Hospital, 95 Dunsanseo-ro, Seo-gu, Daejeon 35233, Korea, lammoth@naver.com

Received 28 April 2019 Accepted 10 May 2019

Korean Diabetes Association

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Management of hyperglycemia limits progression of microvascular complications in type 2 diabetes mellitus (T2DM). According to large-scale randomized control studies to demonstrate the cardiovascular safety of sodium-glucose cotransporter 2 (SGLT2) inhibitors, SGLT2 inhibitors showed not only cardiovascular safety, but also cardiovascular benefits. Heart failure is adequately prevented by SGLT2 inhibitors regardless of history of heart failure. Additionally, SGLT inhibitors also showed renal protective benefits in slowing the decline of glomerular filtration rate and reducing proteinuria. SGLT2 inhibitors are beneficial to T2DM patients with established cardiovascular disease, high risk of heart failure, and renal impairment. As oral hypoglycemic agents, SGLT2 inhibitors not only control the serum glucose level, but also reduce the macrovascular complications of T2DM.

Keywords: Canagliflozin, Dapagliflozin, Diabetes mellitus, type 2, Empagliflozin

Figures and Tables

Table 1

Summary of sodium-glucose cotransporter 2 inhibitors cardiovascular outcomes trials

Values are presented as number only or number (%).

EMPA-REG OUTCOME, Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients; CANVAS, The Canagliflozin Cardiovascular Assessment Study; DECLARE-TIMI 58, Dapagliflozin Effect on CardiovascuLAR Events; eGFR, estimated glomerular filtration rate.

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