Journal List > Int J Thyroidol > v.12(1) > 1126562

Jung: Understanding Neoplasm of Uncertain or Unknown Behavior of the Thyroid in Korean Clinical Practice

Abstract

Thyroid tumors include a heterogeneous group of entities with variable clinical behavior and histology, mostly classified as benign or malignant. Neoplasm of uncertain or unknown behavior in thyroid gland was newly adopted by the 2017 edition of World Health Organization (WHO) classification of endocrine organs. The borderline thyroid tumors include a hyalinizing trabecular tumor and three encapsulated follicular-patterned thyroid tumors (follicular tumor of uncertain malignant potential, well-differentiated tumor of uncertain malignant potential, and non-invasive follicular thyroid neoplasm with papillary-like nuclear features). This review summarizes the changes in the 2017 WHO classification of thyroid tumors, highlights their implications for clinical practice in Korea, and briefly discusses National Health Insurance system, cancer insurance policies, and their associated benefits in Korea.

Figures and Tables

Fig. 1

Schematic illustration of encapsulated follicular-patterned thyroid tumors on the basis of presence or absence of nuclear features of papillary thyroid carcinoma and capsular or vascular invasion by 2017 World Health Organization classification. EFVPTC: encapsulated follicular variant of papillary thyroid carcinoma, FT-UMP: follicular tumor of uncertain malignant potential, NIFTP: non-invasive follicular thyroid neoplasm with papillary-like nuclear features, WDC-NOS: well-differentiated carcinoma, not otherwise specified, WDT-UMP: well-differentiated tumor of uncertain malignant potential

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Table 1

Updates in nomenclature and classification of the 2017 World Health Organization (WHO) Classification of thyroid tumors

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ICD-O: International Classification of Diseases for Oncology, ICD-10: the 10th revision of the International Statistical Classification of Diseases and Related Health Problems, FTC: follicular thyroid carcinoma, KCD-7: the 7th revision of Korean Standard Classification of Diseases, NOS: not otherwise specified, PTC: papillary thyroid carcinoma

Table 2

ICD-10 and KCD-7 diagnosis codes for non-neoplastic thyroid nodules

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ICD-10: the 10th revision of the International Statistical Classification of Diseases and Related Health Problems, KCD-7: the 7th revision of Korean Standard Classification of Diseases

Table 3

Copayment rates for the thyroid and parathyroid tumors according to disease severity in Korea

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*Copayment rate for total health care costs covered by the National Health Insurance Program.

ICD-10: the 10th revision of the International Statistical Classification of Diseases and Related Health Problems, KCD-7: the 7th revision of Korean Standard Classification of Diseases

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