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Cha, Chung, and Hong: The Serum Alpha-antitrypsin Concentration of Coal Workers' Pneumoconiosis Patients
Original Article

Korean Journal of Occupational and Environmental Medicine 1990; 2(1): 34-43.

Published online: 1 February 2019

DOI: https://doi.org/10.35371/kjoem.1990.2.1.34

The Serum Alpha-antitrypsin Concentration of Coal Workers' Pneumoconiosis Patients

Bong Suk Cha, Ho Keun Chung, Jeong Pyo Hong

Department of Preventive Medicine, Yonsei University, Wonju College of Medicine, Korea.

Institute of Occupational Diseases Korea Labour Welfare Corporation, Korea.

Copyright © 1990 The Korean Society of Occupational and Environmental Medicine

Abstract

This study was performed to investigate associations between serum alpha(1)-antitrypsin(AAT) concentration and radiological categories of coal workers' pneumoconlosis(CWP), between AAT concentration and pulmonary complications such as tuberculosis and emphysema, and to study associations between AAT concentration and FEV(1.0)% in CWP patients, We classified 254 CWP patients in D Hospital into categories of small opacity profusion. And we selected 86 subjects by with or without emphysematous finding in each categories by proportional stratified sampling method.
Semm AAT concentrations were quantkated by single radial immunodiffusion method, and the findings of chest radiographs were evaluated by radilogist.
The results were as follows:
1. Serum AAT concentrations were not significantly different among groups of radiological categories of small opacities.
2. Complication of emphysema was associated with smoking habits sigmficantlyl(chi square=12.16, p<0,01). And AAT concentraLion was higher in smokers and ex-smokers than in non-smokers. Serum AAT concentration was significantly higher in the cases with emphysema than in the cdses without emphybema{p<0.01).
3. Serum AAT concentration of the group with active pulmonary tuberculosis was significantly higher than with inactive or without: pulmonary tuberculosis group(p<0.1).
4. Serum AAT concentration of the group with low FEV(1.0)% was significantly higher than with high or normal group(p<0.05).

Keywords: alpha1-antitrypsin, coal workers pneumoconiosis, emphysema, pulmonary tuberculosis, FEV1.0%, smoking habits

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