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Kirn, Nam, Bae, Ha, Kim, Kang, and Lee: A Survey of Hepatitis B Virus Markers by EIA Method among Steel Manufacturing Workers
Original Article

Korean Journal of Occupational and Environmental Medicine 1996; 8(2): 249-257.

Published online: 1 February 2019

DOI: https://doi.org/10.35371/kjoem.1996.8.2.249

A Survey of Hepatitis B Virus Markers by EIA Method among Steel Manufacturing Workers

Jung Gu Kirn, Bbk Dong Nam, Sam Deug Bae, Myung Wha Ha, Doo Hie Kim, Seung Won Kang, Jong Young Lee

Health Care Center, POSCO, Po.hang, Korea.

Department of Preventive Medicine, College of Medicine, Dongguk University, Korea.

Department of Preventive Medicine and Public Health, School of Medicine, Kyungpook National University, Korea.

Copyright © 1996 The Korean Society of Occupational and Environmental Medicine

Abstract

A study for seroprevalence of Hepatitis B virus markers (HBsAg, Anti-HBs, HBeAg and Anti-HBe) by EIA method and the Liver Function Test(SGOT and SGPT) using kinetic method was carried :out from January; to October 1995 :among male workers of a .major iron and steel manufacturing company, located, in Pohang.
The results were as follows;
1. The distribution of hepatitis B virus markers showed that the proportions of HBsAg(+)/Anti-HBs (-), HBsAg(-)/Anti-HBs (+) 'and HBsAg(+)/Anti-HBs (+) were 8.1%, 60.5% and 0.1%, respectively. The positive rate of HBsAg in all subjects was 8.2% whereas that of anti-HBs was 60.6%.
2. The proportions of HBsAg(+)/Anti-HBs (-) and HBsAg(-)/Anti-HBs (+) increased significantly with age. While the distribution of hepatitis B virus markers exhibited no significant differences among the groups classified by educational background or work type.
3. The proportion of drinkers in HBsAg (+)/Anti-HBs (-) (73; 9%) was significantly lower than those of HBsAg (-)/Anti-HBs (-) and HBsAg (-)/Anti-HBs (+) (84.6% and 85.7% respectively). The proportions of smoking for the three groups of HBsAg (-)/Anti-HBs(+),-HBsAg (+)/Anti-HBs (-) and HBsAg (-)/Anti-HBs (-) were 54.3%, 53.7% and 53.0%, respectively (p<0.01). The proportion of the subjects with abnormal liver function test in HBsAg (+)/Anti-HBs (-) was 40.1%, whereas those in HBsAg (-)/Anti-HBs (-) and HBsAg(-)/Anti-HBs (+) were 21.9% and 18.4%, respectively.
4. The distribution of e Ag markers among HBsAg (+) subjects showed that the proportions of HBeAg(+)/Anti-HBe(-), HBeAg(-)/Anti-HBe(+) and HBeAg(+)/Anti-HBe(+) were 31.3%, 55.0% and 1.6%, respectively. The proportion of HBeAg(+)/Anti-HBe(-) decreased significantly with age and those of HBeAg(-)/Anti-HBe(-) and HBeAg(-)/Anti-HBe(+) increased with age. The positive rate of HBeAg among HBsAg (+) subjects was 32.9%.
In conclusion, as a screening method, EIA is. recommended to test hepatitis B virus markers, especially when examining Anti-HBs more sensitively. For the workers of the iron and steel manufacturing company studied, liver diseases caused by other than hepatitis B should be given a special care including an education avoiding alcohol drinking.

Keywords: Epidemiology, Hepatitis B Virus Markers, Iron and Steel Manufacturing Workers

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