This study was carried out to assess the effect of economic depression on psychosocial distress, and to assess the relationship between differences of psychosocial distress and job characteristics (job strain), and to find out the effect of social support on psychosocial distress. We measured job characteristics(job demand, job control), and social support(coworker support, supervisor supports) at work by a self-administered questionnaire. Psychosocial distress was measured by PWI(Psychosocial Well-being Index), a 45-item self-administered instrument. Among the 152 respondents, the prevalence of high job strain was 27% (41 persons). The Odds ratio of high job strain was 3.11 (95% CI; 2.12~4.11), and those of passive group and active group were 2.01(95% CI; 0.83~2.76) and 1.80(95% CI; 0.83~2.76), respectively. Our results supported the association between psychosocial distress and job strain. The odds ratio of high strain isolates group (high strain group+low social support) was 3.59 (95% CI; 2.05~5.13), but the odds ratio of high strain collective group was 1.32 (95% CI; 0.23~2.41). Social support at work was modifying factor of the association between psychosocial distress and job strain. Therefore we reviewed the evidence that economic depression was associated with psychosocial distress in this study, and that the strength of the social support was important in maintain health.