In order to investigate the relationship between stress and fatigue of research workers, we surveyed 246 research workers from September 15 to October 20, 1997. The results were as follows ; 1. Females, 20~29 years of ages, singles are associated with significantly higher stress symptoms and fatigue symptoms 2. The research workers who drink nearly everyday complained significantly lower stress symptoms and fatigue symptoms. 3. The research workers who excercise regularly complained significantly lower stress symptoms and fatigue symptoms. 4. The research workers who are somewhat satisfied by Job and income complained lower stress symptoms and fatigue symptoms. 5. The high risk stress group was 4.5 % of the research workers. The latent stress group was 93.9 % and healthy group was 1.6 %. The research workers belonged to high risk stress group complained significantly higher fatigue symptoms.