Journal List > Korean J Occup Environ Med > v.14(2) > 1125976

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Cheong, Choi, Park, Yun, Kim, Ha, Yang, and Kim: Quantitative Assessment of Magnetic Resonance Imaging for the Noninvasive Evaluation of Bone Marrow Cellularity in Workers with Long-term Exposure to Solvents
Original Article

Korean Journal of Occupational and Environmental Medicine 2002; 14(2): 183-198.

Published online: 30 January 2019

DOI: https://doi.org/10.35371/kjoem.2002.14.2.183

Quantitative Assessment of Magnetic Resonance Imaging for the Noninvasive Evaluation of Bone Marrow Cellularity in Workers with Long-term Exposure to Solvents

Hae Kwan Cheong, Dae Seob Choi, Keon Uk Park, Hwan Jung Yun, Jung Ran Kim, Kyung Im Ha, Seoung Oh Yang, Yang Ho Kim

Department of Preventive Medicine, Dongguk University College of Medicine, Korea.

Department of Radiology, Dongguk University College of Medicine, Korea.

Department of Internal Medicine, Dongguk University College of Medicine, Korea.

Department of Pathology, Dongguk University College of Medicine, Korea.

Department of Clinical Pathology, Dongguk University College of Medicine, Korea.

Department of Internal Medicine, Chungnam University College of Medicine, Korea.

Department of Radiology, Ulsan University Hospital, Korea.

Department of Environmental and Occupational Medicine, Ulsan University Hospital, Korea.

hkcheong@dongguk.ac.kr

Copyright © 2002 The Korean Society of Occupational and Environmental Medicine

Abstract

OBJECTIVES

To develop a quantitative and noninvasive method of bone marrow cellularity evaluation in solvent-exposed painters.

METHODS

Six painters (mean age 46.5 years, 5 males and one female) with hypocellular marrow, and 132 controls were examined using magnetic resonance imaging (MRI). A full examination of the peripheral blood and a bone marrow biopsy was done on each patient. Signal intensities were measured at the vertebral bodies from T12 to S1 on both the T1- and the T2-weighted image (T1WI and T2WI). Signal indices were calculated by dividing the signal indices of the vertebral bodies by that of the paraspinal muscle and the subcutaneous fat in the same view.

RESULTS

The Bone marrow cellularities of the cases painters were between 20.3% and 33.6%. Signal indices based on the muscle at T1WI were greater in the cases of the painters compared to those of the controls (p<0.05, p<0.01). Signal indices based on the muscle at T1WI were significantly higher in older women compared with men (p< 0.05 ) . After adjusting for age and gender, the signal index of cases at S1 based on muscle of T1WI was higher than that of the controls by 0.364. Five of the six cases had a muscle signal index at S1 of T1WI higher than the mean + 1 standard deviation for the same age group and gender.

CONCLUSIONS

MR signal indices are influenced by constitutional factors such as fat content, bone density, and the presence of other pathology. However, after adequate adjustment, it can be used as a useful indicator of bone marrow cellularity in a high-risk population.

Keywords: Magnetic resonance imaging, Bone marrow diseases, Leukopenia, Solvents, Occupational exposure

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