Abstract
Background
Sarcoidosis is a systemic granulomatous disease that can affect any organ, the exact cause of which is uncertain. Currently, investigations of crystalline silica improve the mechanism how it works the course of autoimmune diseases and some hypothesis supports that it also can attribute to sarcoidosis.
Case report
The patient was a 53-year-old male, who works as a stonemason for 30 years. Sarcoidosis was suspected based on his chest X-ray and CT(Computed tomography). A biopsy was performed and he was indeed diagnosed with sarcoidosis.
Conclusion
It is thought that sarcoidosis is more prevalent in the people who work at places with a risk of exposure to crystalline silica. This case suggests that if a patient gets sarcoidosis after being exposed to crystalline silica, or after once being diagnosed with silicosis, his or her sarcoidosis may have occurred due to exposure to crystalline silica.
References
1. Fernández Fabrellas E. [Epidemiology of sarcoidosis]. Arch Bronconeumol. 2007. 43(2):92–100.
2. Rafnsson V, Ingimarsson O, Hjalmarsson I, Gunnarsdottir H. Association between exposure to crystalline silica and risk of sarcoidosis. Occup Environ Med. 1998. 55:657–660.
3. Statement on sarcoidosis. Joint Statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999. 160:736–755.
4. Kang EH. Sarcoidosis in Korea: Revisited. J Korean Med Assoc. 2008. 51(10):925–932.
5. Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med. 2007. 357:2153–2165.
6. Nunes H, Soler P, Valeyre D. Pulmonary sarcoidosis. Allergy. 2005. 60:565–582.
7. Baughman RP, Lower EE, du Bois RM. Sarcoidosis. Lancet. 2003. 361:1111–1118.
8. James DG, Sharma OP. From Hutchinson to now: a historical glimpse. Curr Opin Pulm Med. 2002. 8:416–423.
9. du Bois RM, Goh N, Mcgrath D, Cullinan P. Is there a role for microorganisms in the pathogenesis of sarcoidosis? J Intern Med. 2003. 253:4–17.
10. Moller DR. Etiology of sarcoidosis. Clin Chest Med. 1997. 18:695–706.
11. Iannuzzi MC, Fontana JR. Sarcoidosis: clinical presentation, immunopathogenesis, and theapeutics. JAMA. 2011. 305(4):391–399.
12. Baughman RP, Culver DA, Judson MA. A concise review of pulmonary sarcoidosis. Am J Respir Crit Care Med. 2011. 183:573–581.
13. Robert P, Baughman RP, Lower EE. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Banchereau J, Steinman RM, editors. Sarcoidosis. Harrison's Principles of Internal Medicine. 2008. 17th ed. New York: McGraw-Hill;2135–2145.
14. Taflin C, Miyara M, Nochy D, Valeyre D, Naccache JM, Altare F, ek-Peyron P, Badoual C, Bruneval P, Haroche J, Mathian A, Amoura Z, Hill G, Gorochov G. FoxP3+ regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions. AM J Pathol. 2009. 174:497–508.
15. Kucera GP, Rybicki BA, Kirkey KL, Coon SW, Major ML, Maliarik MJ, Iannuzzi MC. Occupational risk factors for sarcoidosis in african-american siblings. Chest. 2003. 123:1527–1535.
16. Barnard J, Rose C, Newman L, Canner M, Martyny J, McCammon C, Bresnitz E, Rossman M, Thompson B, Rybicki B, Weinberger SE, Moller DR, McLennan G, Hunninghake G, DePalo L, Baughman RP, Iannuzzi MC, Judson MA, Knatterud GL, Teirstein AS, Yeager H Jr, Johns CJ, Rabin DL, Cherniack R. ACCESS Research Group. Job and industry classifications associated with sarcoidosis in a case-control etiologic study of sarcoidosis. J Occup Environ Med. 2005. 47:226–234.
17. Demedts M, Wells AU, Antó JM, Costabel U, Hubbard R, Cullinan P, Slabbynck H, Rizzato G, Poletti V, Verbeken EK, Thomeer MJ, Kokkarinen J, Dalphin JC, Taylor AN. Interstitial lung diseases: an epidemiological overview. Eur Respir J Suppl. 2001. 32:2s–16s.
18. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008. 214:199–210.
19. Maeda M, Nishimura Y, Kumagai N, Hayashi H, Hatayama T, Katoh M, Miyahara N, Yamamoto S, Hirastuka J, Otsuki T. Dysregulation of the immune system caused by silica and asbestos. J Immunotoxicol. 2010. 7:268–278.
20. Steenland K, Brown D. Mortality study of gold miners exposed to silica and nonasbestiform amphibole minerals: an update with 14 more years of follow-up. Am J Ind Med. 1995. 27:217–219.
21. Parks CG, Conrad K, Cooper GS. Occupational exposure to crystalline silica and autoimmune disease. Environ Health Perspect. 1999. 107:Suppl 5. 793–802.
22. Brown JM, Archer AJ, Pfau JC, Holian A. Silica accelerated systemic autoimmune disease in lupus-prone New Zealand mixed mice. Clin Exp Immunol. 2003. 131(3):415–421.
23. Yeager H, Gopalan S, Mathew P, Lawless O, Bellanti JA. Sarcoidosis: Can a murine model help define a role for silica? Med Hypotheses. 2012. 78(1):36–38.
24. Sola R, Boj M, Hernandez-Flix S, Camprubi M. Silica in oral drugs as a possible sarcoidosis-inducing antigen. lancet. 2009. 373(9679):1943–1944.