Journal List > Allergy Asthma Respir Dis > v.7(1) > 1125516

Allergy Asthma Respir Dis. 2019 Jan;7(1):3-12. Korean.
Published online Jan 30, 2019.
© 2019 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
Biologic agents for asthma treatment
Sung-Ryeol Kim and Jae-Hyun Lee
Division of Allergy and Immunology, Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.

Correspondence to: Jae-Hyun Lee. Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Korea. Tel: +82-2-2228-1987, Fax: +82-2-393-6884, Email:
Received Jun 26, 2018; Revised Jan 18, 2019; Accepted Jan 18, 2019.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (


Most treatment strategies for asthma currently include inhaled corticosteroids, with the addition of long-acting beta-2-agonists or leukotriene modifiers, if necessary. However, some patients may not respond to conventional treatment. A better understanding of the pathophysiology of asthma has recently led to the development of biological agents, which have shown promising results for symptom control and future risk reduction in severe asthmatics. This article reviews currently available biologic agents, introduces related studies, and describes the subgroup of patients benefitting from each of biologic agents in the view point of precision medicine.

Keywords: Asthma; Biologic therapy; Precision medicine; Personalized medicine



This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (Ministry of Science, ICT & Future Planning) (No. 2015R1C1A1A02036533).

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