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Allergy Asthma Respir Dis. 2019 Jan;7(1):22-27. Korean.
Published online Jan 30, 2019.  https://doi.org/10.4168/aard.2019.7.1.22
© 2019 The Korean Academy of Pediatric Allergy and Respiratory Disease; The Korean Academy of Asthma, Allergy and Clinical Immunology
Clinical usefulness of serum procalcitonin to distinguish between viral pneumonia and Mycoplasma pneumonia in children: A multicenter, cross-sectional study
Sungmin Kim,1 Gye Hur,1 Myong Soon Sung,1 Hey-Sung Baek,2 Jung Won Yoon,3 Sun Hee Choi,4 Youn Ho Sheen,5 and Man Yong Han6
1Department of Pediatrics, Inje University Haeundae Paik Hospital, Busan, Korea.
2Department of Pediatrics, Kangdong Sacred Heart Hospital, Seoul, Korea.
3Department of Pediatrics, Myongji Hospital, Seonam University College of Medicine, Goyang, Korea.
4Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea.
5Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
6Department of Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Correspondence to: Myong Soon Sung. Department of Pediatrics, Inje University Haeundae Paik Hospital, 875 Haeun-daero, Haeundae-gu, Busan 48108, Korea. Tel: +82-51-797-2000, Fax: +82-51-797-0298, Email: myong47@hanmail.net
Received Jul 23, 2018; Revised Oct 26, 2018; Accepted Oct 27, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/).


Abstract

Purpose

The aim of this study was to compare the clinical usefulness of serum procalcitonin (PCT) levels in Mycoplasma pneumoniae pneumonia (M. pneumonia) and viral pneumonia in children.

Methods

We retrospectively analyzed the medical records of 348 patients admitted between June 2015 and December of 2015. There were 162 patients with M. pneumonia without virus coinfection (group 1) and 186 patients with viral pneumonia (group 2). All subjects had radiographic evidence of pneumonia with available specimens for both M. pneumonia and viral testing, and levels of serum PCT, white blood cell counts (WBC), neutrophil portion, and C-reactive protein (CRP). Fifty-eight children who performed follow-up sampling at the time of no fever for more than 48 hours were subdivided into group 3 (M. pneumonia with follow-up sampling, n=41) and group 4 (viral pneumonia with follow-up sampling, n=17).

Results

No difference was noted in the levels of serum PCT (P=0.168), CRP (P=0.296), WBC (P=0.732), and neutrophil proportion (P=0.069) between groups 1 and 2, after adjusting for age. Serial changes in serum PCT levels between the first and second samples were significant in group 3 (P=0.046). Serial changes in serum CRP levels between the first and second samples were significant in group 4 (P=0.008).

Conclusion

Serum PCT and CRP levels may change differently after infection according to the etiology of pneumonia.

Keywords: Mycoplasma pneumonia; Viral pneumonia; Procalcitonin; Community acquired pneumonia; Child

Tables


Table 1
Clinical characteristics of the study subjects
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Table 2
Comparison of laboratory findings at admission between mycoplasma pneumonia and viral pneumonia
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Table 3
Comparison of laboratory findings at the time of admission and follow-up in groups 3 and 4
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