Renal and Urinary Manifestations of Inflammatory Bowel Disease

Ye Na Kim; Yeonsoon Jung

doi:10.4166/kjg.2019.73.5.260

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Kim and Jung: Renal and Urinary Manifestations of Inflammatory Bowel Disease

Special Review

Extraintestinal Manifestations of Inflammatory Bowel Disease

The Korean Journal of Gastroenterology 2019; 73(5): 260-268.

Published online: 27 May 2019

DOI: https://doi.org/10.4166/kjg.2019.73.5.260

Renal and Urinary Manifestations of Inflammatory Bowel Disease

Ye Na Kim, Yeonsoon Jung

Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

Correspondence to: Yeonsoon Jung, Department of Internal Medicine, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 49267, Korea. Tel: +82-51-990-6360, Fax: +82-51-990-3088, kidney@hanmail.net

Received 10 April 2019 Revised 10 May 2019 Accepted 13 May 2019

Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The incidence of inflammatory bowel disease (IBD) is increasing rapidly and extra-intestinal manifestations in IBD are also increasing. The prevalence of renal and urinary involvement in IBD ranges from 4–23%. Nephrolithiasis is the most common urinary complication in IBD patients. Parenchymal renal disease is rare but has been well documented and presents most commonly as glomerulonephritis or tubulointerstitial nephritis. The overall morbidity of IBD-related renal manifestations is significant. Therefore, a high index of clinical suspicion and optimal monitoring of the renal function are needed for the early diagnosis and prevention of IBD-related renal manifestations and complications.

Keywords: Inflammatory bowel disease, Kidney, Nephrolithiasis, Glomerulopathy, Tubulointerstitial nephritis

Figures and Tables

Fig. 1

Diagnostic approach of renal and urinary manifestations in patients with inflammatory bowel disease. 5-ASA, 5-aminosalicylate; CsA, Cyclosporin A; TNFα, tumor necrosis factor alpha; eGFR, estimated glomerular filtration rate; IBD, inflammatory bowel disease.

Table 1

Renal and Urinary Manifestations of Inflammatory Bowel Disease

C3, complement 3.

Table 2

Drug-associated Nephrotoxicity in Inflammatory Bowel Disease

TNF-α, tumor necrosis factor-alpha.

Notes

^{Financial support} None.

^{Conflict of interest} None.

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ORCID iDs: Yeonsoon Jung
https://orcid.org/0000-0003-3657-7082
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