Dermatologic Manifestations in Inflammatory Bowel Disease

Hyun Yi Suh; Woo Jin Lee; Soo-Young Na

doi:10.4166/kjg.2019.73.5.285

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Suh, Lee, and Na: Dermatologic Manifestations in Inflammatory Bowel Disease

Special Review

Extraintestinal Manifestations of Inflammatory Bowel Disease

The Korean Journal of Gastroenterology 2019; 73(5): 285-293.

Published online: 27 May 2019

DOI: https://doi.org/10.4166/kjg.2019.73.5.285

Dermatologic Manifestations in Inflammatory Bowel Disease

Hyun Yi Suh, Woo Jin Lee, Soo-Young Na¹

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

¹Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju, Korea.

Correspondence to: Soo-Young Na, Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, 15 Aran 13-gil, Jeju 63241, Korea. Tel: +82-64-717-1143, Fax: +82-64-717-1131, sktndud@hanmail.net

Received 8 April 2019 Revised 3 May 2019 Accepted 14 May 2019

Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract with an unknown etiology and pathogenesis. The incidence and prevalence of IBD are increasing rapidly in Korea. Approximately one-third of patients with IBD appear to develop extra-intestinal manifestations with the skin being one of the most commonly affected organs. They may precede, occur simultaneously, or follow the diagnosis of IBD. In addition, they may parallel with the luminal symptoms or independent from the disease activity of IBD. This review outlines the skin manifestations associated with IBD and discusses their management. Skin manifestations should be managed in close collaboration with a dermatologist.

Keywords: Inflammatory bowel diseases, Crohn disease, Colitis, ulcerative, Skin manifestations

Figures and Tables

Fig. 1

Erythema nodosum. Tender, bilateral, erythematous nodules and plaques on the anterior aspect of the lower extremities.

Fig. 2

Pyoderma gangrenosum. Ulcer shows an edematous pale border with granulation tissue on the leg.

Fig. 3

Sweet's syndrome. Erythematous plaques and patches on the extremities and trunk.

Fig. 4

Acrodermatitis enteropathica. (A) Multiple flaccid bullae and vesicles on dorsum of the feet. (B) Hyperpigmented macules and patches with scale resolved on the dorsum of the feet. (C, D) Paronychia.

Fig. 5

TNF-α inhibitor treatment-induced skin manifestations. (A, B) Small plaque psoriasiform lesions scattered over the trunk and palmoplantar pustular psoriasiform lesions following TNF-α inhibitor therapy. (C, D) Generalized blistering skin lesions on the trunk of a 40-year-old woman treated for ulcerative colitis with infliximab. TNF-α, tumor necrosis factor-alpha.

Table 1

Cutaneous Extra-intestinal Manifestations of Inflammatory Bowel Disease

TNF-α, tumor necrosis factor-alpha; IBD, Inflammatory bowel disease; IL, interleukin.

Notes

^{Financial support} None.

^{Conflict of interest} None.

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ORCID iDs: Soo-Young Na
https://orcid.org/0000-0003-3685-6823
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