The Role of Mucus Barrier in Ulcerative Colitis Pathogenesis Using Proteomics

Chang Min Lee

doi:10.4166/kjg.2019.73.5.311

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Lee: The Role of Mucus Barrier in Ulcerative Colitis Pathogenesis Using Proteomics

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The Korean Journal of Gastroenterology 2019; 73(5): 311-312.

Published online: 27 May 2019

DOI: https://doi.org/10.4166/kjg.2019.73.5.311

The Role of Mucus Barrier in Ulcerative Colitis Pathogenesis Using Proteomics

Chang Min Lee

Division of Gastroenterology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.

Correspondence to: Chang Min Lee, Division of Gastroenterology, Department of Internal Medicine, Gyeongsang National University Hospital, 79 Gangnam-ro, Jinju 52727, Korea. Tel: +82-55-750-9783, Fax: +82-55-750-9492, gyrzax@gmail.com

Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Notes

^{Financial support} None.

^{Conflict of interest} None.

References

1. Danese S, Fiocchi C. Ulcerative colitis. N Engl J Med. 2011; 365:1713–1725.

2. Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A. 2008; 105:15064–15069.

3. Van der Sluis M, De Koning BA, De Bruijn AC, et al. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology. 2006; 131:117–129.

4. Velcich A, Yang W, Heyer J, et al. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science. 2002; 295:1726–1729.

5. Nowarski R, Jackson R, Gagliani N, et al. Epithelial IL-18 equilibrium controls barrier function in colitis. Cell. 2015; 163:1444–1456.

6. Birchenough GM, Nyström EE, Johansson ME, Hansson GC. A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science. 2016; 352:1535–1542.

7. Lampinen M, Rönnblom A, Amin K, et al. Eosinophil granulocytes are activated during the remission phase of ulcerative colitis. Gut. 2005; 54:1714–1720.

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ORCID iDs: Chang Min Lee
https://orcid.org/0000-0001-5587-2023
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