Musculoskeletal Manifestation in Inflammatory Bowel Disease

Yun Sung Kim; Jun Lee

doi:10.4166/kjg.2019.73.5.276

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Kim and Lee: Musculoskeletal Manifestation in Inflammatory Bowel Disease

Special Review

Extraintestinal Manifestations of Inflammatory Bowel Disease

The Korean Journal of Gastroenterology 2019; 73(5): 276-284.

Published online: 27 May 2019

DOI: https://doi.org/10.4166/kjg.2019.73.5.276

Musculoskeletal Manifestation in Inflammatory Bowel Disease

Yun Sung Kim, Jun Lee¹

Division of Rheumatology, Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea.

¹Division of Gastroenterology, Department of Internal Medicine, Chosun University College of Medicine, Gwangju, Korea.

Correspondence to: Jun Lee, Division of Gastroenterology, Department of Internal Medicine, Chosun University College of Medicine, 365 Pilmun-daero, Dong-gu, Gwangju 61453, Korea. Tel: +82-62-220-3012, Fax: +82-62-224-5494, leejun@chosun.ac.kr

Received 3 April 2019 Revised 7 May 2019 Accepted 8 May 2019

Korean Society of Gastroenterology

(open-access):

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Almost 50% of patients with inflammatory bowel disease (IBD) exhibit at least one extra-intestinal manifestation in their lifetime. Extra-intestinal manifestations of IBD are often associated with the intestinal disease activity, reducing the quality of life of the patient but rarely leading to fatal complications. Musculoskeletal involvement is the most frequent extra-intestinal manifestation of patients with IBD but this rarely occurs before IBD is diagnosed. They are manifested in various forms, such as arthropathy, fibromyalgia, and osteoporosis. Therefore, a multidisciplinary team approach including gastroenterologists and rheumatologists are necessary for optimal treatment. This review focuses on the diagnosis and treatment of musculoskeletal manifestations of IBD from the perspectives of rheumatologists who can assist gastroenterologists.

Keywords: Inflammatory bowel diseases, Musculoskeletal diseases, Joint diseases

Figures and Tables

Fig. 1

Patients show the swelling of the left Achilles tendon indicating Achilles tendinitis (arrows).

Fig. 2

Patients shows the swelling of the right 4-5th toes (arrows).

Fig. 3

Simple X-ray shows erosion and sclerosis in the sacroiliac joint space (arrows).

Fig. 4

Simple X-ray shows vertebral body fusion that resembles a bamboo stem in ankylosing spondylitis (arrows).

Table 1

Classification of Muscloskeletal Manifestations in Inflammatory Bowel Disease1

IBD, inflammatory bowel disease; NSAIDs, nonsteroidal anti-inflammatory drugs; HLA, human leukocyte antigen; COX-2, cyclooxygenase-2; MTX, methotrexate; TNF, tumor necrosis factor.

Notes

^{Financial support} None.

^{Conflict of interest} None.

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ORCID iDs: Jun Lee
https://orcid.org/0000-0002-8060-9646
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