Journal List > Ann Occup Environ Med > v.27(1) > 1124869

Park, Nam, Lee, Oh, Kang, and Koh: Association between night work and cardiovascular diseases: analysis of the 3rd Korean working conditions survey

Abstract

Objectives

This study was conducted to investigate the relationship between night work and cardiovascular diseases among wage workers in Korea.

Methods

The study was based on the 3rd Korean Working Conditions Survey (KWCS; 2011). This study included 29,711 wage workers. We used the chi-squared test and logistic regression to examine the association between cardiovascular diseases and night work and cumulative night work.

Results

Among all of the paid workers, 12.5% reported doing night work ≥ 1 day per month. Night work was significantly associated with an increased risk of cardiovascular diseases (odds ratio [OR] 1.58, 95% confidence interval [CI] 1.11-2.25). Also, compared to the group that did not do night works, the group with higher cumulative night work demonstrated an increased risk for cardiovascular diseases (OR 1.81, 95% CI 1.19-2.74).

Conclusions

This study suggests that night work is significantly associated with cardiovascular diseases.

Introduction

Night work is currently common throughout the world. Shift work including a night work is being widely adopted in many places including China, the Republic of Korea, and other countries in Asia and Europe. In China, 36.1% of employees are shift workers, and in Korea more than 30% of those in the service industry do shift-based work [1]. In the EU-25, 17.7% of all employees do shift work [1]. Night work in the shift-based work system is thus also increasing accordingly. In Chile, Czechoslovakia, and China, 15-24% of employees work at night [2-4]. Some workers in Brazil (9.0%) and Hungary (9.5%) also do night work on a regular basis [5,6]. In the meantime, shift work including night work is known to be related with chronic diseases such as cardiovascular diseases, metabolic syndrome, diabetes, and breast cancer [7].
Shift work, in particular, is a risk factor for cardiovascular diseases. Wang et al. [7] noted, however, that the association between shift work including night work and cardiovascular diseases is controversial. Shift work has been reported to be linked with an increased risk for cardiovascular diseases in cohort studies [8,9]. The underlying mechanism includes changes in lifestyle factors caused by disruption of circadian rhythms and an increase in psychosocial stress. Shift workers have a reversed sleep-wake cycle, experiencing disrupted circadian rhythms. This leads to a higher stress level and adverse changes in lifestyle factors such as smoking and eating habits [10,11]. In addition, shift work is associated with an increase in cardiovascular diseases risk factors such as hypertension and obesity. The hike in the risk of those conditions due to shift work may also result in a higher risk for cardiovascular diseases [12,13].
In the meantime, few studies have examined the association between night work and cardiovascular diseases, or the risk factors for such diseases in Korean workers. Some studies have reported links between the period of shift work and risk factors for cardiovascular diseases —blood pressure, serum cholesterol level, Body Mass Index (BMI), Waist-Hip Ratio (WHR), and fasting glucose [13]. Furthermore, studies have been carried out on the association between shift work and cardiovascular symptoms [14] and between shift work and metabolic syndrome [15]. However, the subjects of those studies were limited to women [14,15], or had specific occupations such as nurses [13]. In other words, there has been no study using large-scale national data. Therefore, in this study, we intended to identify any association between night work and cardiovascular diseases based on large-scale national data representative of the population of the Republic of Korea as a whole.

Materials and methods

Study subjects

This study is based on the 3rd Korean Working Conditions Survey (KWCS) of 2011. The KWCS has been conducted since 2006, showing the current trends in working conditions, health, and occupational hazards of Korean employees. The 3rd KWCS was conducted from June 1, 2011 to November 30, 2011. The survey was administered to workers over 15 years old who had done paid work for more than one hour during the past week at the time of the survey. A total of 50,032 workers were surveyed. We restricted the population of study to paid workers, and thus 29,711 participants were included.

General characteristics

The general characteristics collected in the KWCS included the following: sex; age (<30 years, 30-39 years, 40-49 years, 50-59 years, or ≥ 60 years); level of education completed (middle school or below, high school, or college or above); monthly income (<1 million won, 1 million-2 million won, 2 million-3 million won, or ≥ 3 million won); smoking status (non-smoker, ex-smoker, or current smoker); frequency of drinking alcohol (none, ≤ 1 drink per week, or ≥ 2 drinks per week); diagnosis of hypertension (yes or no); and diagnosis of obesity (yes or no). Hypertension and obesity were assessed with the question, “Have you ever been told by your doctor that you have (A) hypertension or (B) obesity?”

Occupational characteristics

The occupational characteristics surveyed included the following: occupation type (white collar, service, or blue collar); company size by current number of employees (<5, 5-49, 50-299, or ≥ 300); years of service (<1 year, 1-9 years, ≥ 10 years); shift work status (yes or no); and working time (<40 hours a week, 40-48 hours a week, 49-60 hours a week, or ≥ 61 hours a week).

Night work and cumulative night work

For this analysis, we defined night work as at least two hours of work between 10 pm and 5 am. Night workers were defined as those doing at least one night work within a month. Cumulative night work was calculated by multiplying the number of months worked by the number of night work done. Based on the mean (360), we categorized the subjects into a low risk group (those with < mean) and high risk group (those with ≥ mean). The analysis was performed using a group that had done no night work as the reference group.

Cardiovascular diseases

To examine the subjects' history of cardiovascular diseases, the following question was asked: “Have you had any cardiovascular disease in the past 12 months?” Respondents answering "Yes" were considered to have cardiovascular diseases.

Statistical analysis

We conducted a descriptive analysis on the general and occupational characteristics of the subjects surveyed. The crude odds ratio (OR) between cardiovascular diseases and night work and the 95% confidence interval (CI) were calculated using simple logistic regression analysis. In addition, the adjusted OR and 95% CI were calculated through multivariate logistic regression analysis after correcting for general and occupational characteristics. The analysis models according to the adjusted variables were as follows: (i) Model 1: crude OR; (ii) Model 2: adjusted for sex, age, level of education completed, and monthly income; (iii) Model 3: Model 2 + adjusted for smoking status, and frequency of drinking; (iv) Model 4: Model 3 + adjusted for occupation type, company size by the number of employees, shift work status, and working time. P ≤ 0.05 was considered to indicate statistical significance. The data was analyzed using SAS version 9.3.

Results

General characteristics of the study subjects

Among all paid workers, women and men accounted for 41.6% (12,365) and 58.4% (17,346) of the total, respectively. Those in their 30s were the most common (30.0%, 8,919), followed by those in their 40s (28.7%, 8,534), 50s (16.9%, 5,019), under 30 (16.5%, 4,904), and 60 and older (7.9%, 2,335). Concerning the level of education completed, those with college or above comprised the largest proportion (49.8%, 14,791), followed by those with a high school diploma (39.0%, 11,600), and middle school or below (11.2%, 3,320). Among monthly income levels, the largest group had an income in the range of 1-2 million won (39.8%, 11,825), followed by 2-3 million won (27.1%, 8,058), ≥ 3 million (20.3%, 6,041), and < 1 million won (12.7%, 3,780). Concerning the participants' smoking status, 54.9% (16,318) were non-smokers, while 34.1% (10,127) were current smokers and 11.0% (3,266) were ex-smokers. Among those surveyed, 51.0% (15,153) drank ≤ 2 alcoholic drinks a week, while 25.7% (7,634) drank < 1 drink a week. Non-drinkers represented 23.3% (6,924) of the total. There were 1,463 (4.9%) who had been diagnosed with hypertension and 553 (1.9%) diagnosed with obesity. When asked if they had experienced cardiovascular diseases in the past year, 1.1% (335) responded affirmatively.
With regard to occupational characteristics, white collar workers were the largest group, constituting 12,149 (40.9%), while 10,735 were blue collar workers and 6,827 were service workers. As for the size of the workplace, 50.2% (14,478) were working at a site with 5-49 people; 26.3% (7,591) belonged to a site with < 5 workers; 16.4% (4,724) worked at a site with 50-299 workers; 7.1% (2,052) had a workplace with ≥ 300 employees. Concerning the years of service, 60.9% (18,091) reported working for 1-9 years; 23.9% (7,010) had ≥ 10 years' experience; and 15.2% (4,519) had worked for < 1 year. Shift workers accounted for 9.6% (2,839), and the rest (26,872; 90.4%) were not shift workers. With regard to work hours, 52.2% (15,521) worked for 40-48 hours a week, 28.9% (8,571) worked for 49-60 hours a week, 10.0% (2,970) worked < 40 hours a week, and 8.9% (2,649) worked for ≥ 61 hours a week. Those who said they did night work at least once a month constituted 12.5% (3,712), and the rest 87.5% (25,999) said that they did not (Table 1).
Table 1
General characteristics of the study subjects
aoem-27-15-i001
N %
Sex
 Male 17346 58.4
 Female 12365 41.6
Age (years)
 <30 4904 16.5
 30-39 8919 30.0
 40-49 8534 28.7
 50-59 5019 16.9
 ≥60 2335 7.9
Level of education completed
 Middle school or below 3320 11.2
 High school 11600 39.0
 College or above 14791 49.8
Monthly income (Korean won)
 <1,000,000 3780 12.7
 1,000,000 - 2,000,000 11825 39.8
 2,000,000 - 3,000,000 8058 27.1
 ≥3,000,000 6041 20.3
Smoking
 Non-smoker 16318 54.9
 Ex-smoker 3266 11.0
 Current smoker 10127 34.1
Alcohol drinking frequency (drinks)
 None 6924 23.3
 ≤1 per week 7634 25.7
 ≥2 per week 15153 51.0
Job type
 White collar 12149 40.9
 Service 6827 23.0
 Blue collar 10735 36.1
Company size (no. of employees)
 <5 7591 26.3
 5-49 14478 50.2
 50-299 4724 16.4
 ≥300 2052 7.1
Years of service
 <1 4519 15.2
 1-9 18091 60.9
 ≥10 7101 23.9
Shift work
 No 26872 90.4
 Yes 2839 9.6
Working time (hours/week)
 <40 2970 10.0
 40-48 15521 52.2
 49-60 8571 28.9
 ≥61 2649 8.9
Hypertension
 No 28248 95.1
 Yes 1463 4.9
Obesity
 No 29158 98.1
 Yes 553 1.9
Cardiovascular diseases
 No 29376 98.9
 Yes 335 1.1
Night work
 No 25999 87.5
 Yes (≥1 day/month) 3712 12.5

Association between general characteristics and night work

Among the subjects who were night workers, the males comprised a higher proportion (77.4%) of the total than females, and those in their 50s and 60s took up larger shares of the total, while those under 30, and those in their 30s and 40s each constituted lower proportions. Those with high school education and education below middle school accounted for more of the night workers, whereas those with a college education or above appeared less frequently among night workers. Regarding average monthly income, subjects with an income between 2-3 million won and ≥ 3 million were more common among night workers; those with < 1 million won accounted for a smaller proportion. Concerning the smoking status, there were more current smokers and ex-smokers among night workers (44.3% and 16.4%, respectively) than among workers without night work (32.6% and 10.2%). The proportions of those who drink ≥ 2 alcoholic drinks per week and those who do not drink at all were smaller among night workers than in the other workers, while the share of those who drink ≤ 1 per week was higher in the night workers. There were more who had been diagnosed with hypertension in the night worker group than among the other workers (6.9% and 4.6%, respectively). There were also more who had been diagnosed with obesity among the night workers than in rest of the workers (2.8% and 1.7%, respectively). The share of those who said they had experienced cardiovascular diseases was larger among the night workers (1.8%) than in those who did not work night work (1.0%). All of the aforementioned variables showed statistically significant differences.
Among the subjects, there were more blue collar workers among the night workers (52.0%) than in the other workers (33.9%), whereas white collar workers and service workers were fewer in the night workers. The subjects who work for sites with 50-299 employees and sites with ≥ 300 workers were more common in night workers (22.8% and 14.1%, respectively) than workers without night work (15.5% and 6.1%, respectively). The shares of workers who belong to sites with < 5 employees and 5-49 employees were smaller in the night worker group. Concerning the years of service, there were more who had worked ≥ 10 years in the night workers, and there were fewer of those who had worked < 1 year or had worked for 1-9 years among the night workers. A much greater proportion of night workers (50.6%) than the other workers (3.7%) were involved in shift work. The shares of those who work for 49-60 hours and for ≥ 61 hours were higher in the night workers (32.8% and 24.8%, respectively) than non-night workers (28.3% and 6.6%, respectively), while the proportion of those who work < 40 hours or 40-48 hours a week were lower in the night workers. All of the aforementioned variables showed statistically significant differences (Table 2).
Table 2
Association between general characteristics and night work
aoem-27-15-i002
Night work p value*
Yes (N  = 3712) No (N =  25999)
N % N %
Sex
 Male 2872 77.4 14474 55.7 <.0001
 Female 840 22.6 11525 44.3
Age (years)
 <30 596 16.1 4308 16.6 <.0001
 30-39 1025 27.6 7894 30.4
 40-49 941 25.4 7593 29.2
 50-59 669 18.0 4350 16.7
 ≥60 481 13.0 1854 7.1
Level of education completed
 Middle school or below 492 13.3 2828 10.9 <.0001
 High school 1683 45.3 9917 38.1
 College or above 1537 41.4 13254 51.0
Monthly income (Korean won)
 <1,000,000 364 9.8 3416 13.1 <.0001
 1,000,000 - 2,000,000 1421 38.3 10404 40.0
 2,000,000 - 3,000,000 1070 28.8 6988 26.9
 ≥3,000,000 857 23.1 5184 19.9
Smoking
 Non-smoker 1460 39.3 14858 57.2 <.0001
 Ex-smoker 608 16.4 2658 10.2
 Current smoker 1644 44.3 8483 32.6
Alcohol drinking frequency (drinks)
 None 677 18.2 6247 24.0 <.0001
 ≤1 per week 1179 31.8 6455 24.8
 ≥2 per week 1856 50.0 13297 51.1
Job type
 White collar 1023 27.6 11126 42.8 <.0001
 Service 758 20.4 6069 23.3
 Blue collar 1931 52.0 8804 33.9
Company size (no. of employees)
 <5 627 17.4 6964 27.6 <.0001
 5-49 1634 45.3 12844 50.9
 50-299 822 22.8 3902 15.5
 ≥300 523 14.5 1529 6.1
Years of service
 <1 539 14.5 3980 15.3 0.0004
 1-9 2190 59.0 15901 61.2
 ≥10 983 26.5 6118 23.5
Shift work
 No 1833 49.4 25039 96.3 <.0001
 Yes 1879 50.6 960 3.7
Working time (hours/week)
 <40 197 5.3 2773 10.7 <.0001
 40-48 1377 37.1 14144 54.4
 49-60 1216 32.8 7355 28.3
 ≥61 922 24.8 1727 6.6
Hypertension
 No 3457 93.1 24791 95.4 <.0001
 Yes 255 6.9 1208 4.6
Obesity
 No 3607 97.2 25551 98.3 <.0001
 Yes 105 2.8 448 1.7
Cardiovascular diseases
 No 3647 98.2 25729 99.0 <.0001
 Yes 65 1.8 270 1.0
*based on a chi-squared test.

Odds ratios of cardiovascular diseases associated with night work

Night work was found to have a significant association with cardiovascular diseases. When the group that does night work ≥ 1 day per month and the group which does not were compared, the crude OR and 95% CI of night work was 1.70 (1.29-2.23). The OR and 95% CI after correcting general and occupational characteristics were as follows: Model 2 (OR 1.44, 95% CI 1.09-1.92); Model 3 (OR 1.42, 95% CI 1.07-1.89); Model 4 (OR 1.58, 95% CI 1.11-2.25) (Table 3).
Table 3
Odds ratios of cardiovascular disease associated with night work
aoem-27-15-i003
Model 1 Model 2 Model 3 Model 4
OR 95% CI OR 95% CI OR 95% CI OR 95% CI
Cardiovascular diseases
Reference group 1.00 1.00 1.00 1.00
Night work (≥1 day/month) 1.70 1.29 - 2.23 1.44 1.09 - 1.92 1.42 1.07 - 1.89 1.58 1.11 - 2.25
OR, odds ratio; CI, confidence interval.
Model 1: odds ratio by independent univariate logistic regression analysis.
Model 2: multivariate logistic regression analysis, model 1 + gender (male or female), age (<30 years, 30-39 years, 40-49 years, 50-59 years, or ≥60 years, level of education completed (middle school or below, high school, or college or above), monthly income (<1,000,000 won, 1,000,000 - 2,000,000 won, 2,000,000 - 3,000,000 won, or ≥3,000,000 won).
Model 3: multivariate logistic regression analysis, model 2 + smoking (non-smoker, ex-smoker or current smoker), and drinking frequency (none, ≤1 per week, ≥2 per week).
Model 4: multivariate logistic regression analysis, model 3 + job type (white collar, service, or blue collar), company size by number of employees (<5, 5-49, 50-299, or ≥300), shift work (yes or no), and working time (<40 hours a week, 40-48 hours a week, 49-60 hours a week, or ≥61 hours a week).

Odds ratios of cardiovascular diseases associated with cumulative night work

We measured cumulative night work by multiplying the number of night work done per month by the number of months worked. We divided the participants into low-risk and high-risk groups based on the mean, and compared them with the reference group which did not do night work, and analyzed the results. There was no significant increase in the risk of cardiovascular diseases in the low risk group compared to the reference group (Model 1: Crude OR 1.26, 95% CI 0.82-1.93; Model 2: OR 1.25, 95% CI 0.81-1.94; Model 3: OR 1.23, 95% CI 0.79-1.90; Model 4: OR 1.34, 95% CI 0.84-2.14). The high risk group demonstrated a significant increase in the risk in all models compared to the reference group (Model 1: Crude OR 2.10, 95% CI 1.51-2.92; Model 2: OR 1.58, 95% CI 1.12-2.22; Model 3: OR 1.56, 95% CI 1.11-2.20; Model 4: OR 1.81, 95% CI 1.19-2.74) (Table 4).
Table 4
Odds ratios of cardiovascular disease associated with cumulative night work
aoem-27-15-i004
Model 1 Model 2 Model 3 Model 4
OR 95% CI OR 95% CI OR 95% CI OR 95% CI
Cardiovascular diseases
Reference group 1.00 1.00 1.00 1.00
Low risk group (<360) 1.26 0.82 - 1.93 1.25 0.81 - 1.94 1.23 0.79 - 1.90 1.34 0.84 - 2.14
High risk group (≥360) 2.10 1.51 - 2.92 1.58 1.12 - 2.22 1.56 1.11 - 2.20 1.81 1.19 - 2.74
OR, odds ratio; CI, confidence interval.
Model 1: odds ratio by independent univariate logistic regression analysis.
Model 2: multivariate logistic regression analysis, model 1 + sex (male or female), age (<30 years, 30-39 years, 40-49 years, 50-59 years, or ≥60 years, level of education completed (middle school or below, high school, or college or above), monthly income (<1,000,000 won, 1,000,000 - 2,000,000 won, 2,000,000 - 3,000,000 won, or ≥3,000,000 won).
Model 3: multivariate logistic regression analysis, model 2 + smoking (non-smoker, ex-smoker or current smoker), and drinking frequency (none, ≤1 per week, ≥2 per week).
Model 4: multivariate logistic regression analysis, model 3 + job type (white collar, service, or blue collar), company size by number of employees (<5, 5-49, 50-299, or ≥300), shift work (yes or no), and working time (<40 hours a week, 40-48 hours a week, 49-60 hours a week, or ≥61 hours a week).

Discussion

This study was conducted to search for an association between night work and cardiovascular diseases in Korean paid workers, using large-scale national data representative of the population. Among all paid employees, those who did a night work ≥ 1 day per month accounted for 12.5%. In the group that did night work, the OR (95% CI) of cardiovascular diseases was 1.58 (1.11-2.25), suggesting a significant association with an increase in the risk of cardiovascular diseases. We speculated that the number of night work done would raise the risk for cardiovascular diseases. For verification, we calculated the cumulative night work, which showed a higher risk of cardiovascular diseases in the group who had greater cumulative night work.
A prior study—a cross-sectional one in Brazil using the Framingham score as an indicator of cardiovascular risk—showed that night shift work was independently associated with an increase in cardiovascular risk [16]. In addition, the hazard ratio of myocardial infarction in German adults doing shift work was 1.53 (95% CI 1.06-2.22) [17]. Literature reviews have revealed a significant association between shift work including night work and cardiovascular diseases [7,11,18]. Cohort studies have also reported significant links between shift work and cardiovascular diseases. According to an observational study following 5,517 Danish workers for 12 years, the relative risk of circulatory disease in nighttime workers compared to daytime workers was 1.31 (95% CI 1.06-1.63) [8]. Another cohort study in which 6,711 Japanese workers were followed for 14 years demonstrated that shift workers had a higher risk of mortality due to ischemic heart disease than daytime workers (relative risk = 2.32, 95% CI 1.37-3.95) [9]. Such results agree with those of this study. Nonetheless, as the definition of cardiovascular diseases and night work and the measurement methods of night work differ in various studies, caution is needed in interpreting the results.
Studies that have analyzed the dose-response relationship between night shift work and cardiovascular diseases include those of Brown et al. (2009) [19] and Kawachi et al. (1995) [20]. Brown et al. reported in their cohort study using the Nurses' Health Study, that with every five years of rotating night shift work, the risk of ischemic stroke went up by 4% (HR = 1.04, 95% CI 1.01-1.07)[19]. Kawachi et al., also using the Nurses' Health Study dataset, stated that the relative risk of coronary heart disease of a group with 6 or more years of rotating night shifts was 1.51 (95% CI 1.12-2.03), compared to the group which did not do shift work [20]. The number of months worked, as used in this study, is not the exact period of the subjects' night work. Therefore, it is not reasonable to compare the risk of cardiovascular diseases with the number of night work done per month alone. Also, as younger and healthier people are more likely to do shift work [11,21], the period of shift work had to be taken into consideration. Therefore, we calculated and analyzed cumulative night work. Consequently, the risk of the low-risk group compared with the group that did not have cumulative night work was not significantly different (OR = 1.34, 95% CI 0.84-2.14). In contrast, the risk of cardiovascular diseases in the high risk group was higher than in the reference group (OR 1.81, 95% CI 1.19-2.74).
Various biological mechanisms behind the link between shift work and cardiovascular diseases have been suggested. Disruption of circadian rhythms, changes in metabolic and hormonal functioning, lifestyle changes including smoking and unhealthy eating habits, and psychosocial stress are some of the examples [7,10,11,18]. Night workers have a polar opposite schedule for work and rest from the standard chronobiological pattern. They sleep when the body is preparing to start activity and have to work when their psychophysical activity is decreased [22]. Such changes in the chronobiological pattern in the human body disrupt the normal circadian rhythms of blood pressure, which drops at night and increases in the morning [22]. In other words, shift work converts the changes of blood pressure in a day from a dipper to non-dipper pattern [23,24]. "Dipper" here refers to the drop of nighttime blood pressure by more than 10% of the average mean arterial pressure. “Non-dipper” means no or minimal drop of the nighttime blood pressure [24]. Such a limited decrease in the nighttime blood pressure due to circadian rhythm disruption (non-dipping pattern) has been reported to increase the risk of cardiovascular diseases [22,25].
In this study, while we did not measure the blood pressure of the subjects, we instead surveyed whether they had been clinically diagnosed with hypertension. In the results, the proportion of those who had been diagnosed with hypertension was higher in the night workers (6.9%) than non-night workers (4.6%). Another study revealed an association between night shift work and hypertension. In a study on 1,838 female workers in one Taiwanese manufacturing company, women who did a night shift showed a significantly higher OR of hypertension than their daytime counterparts (OR 2.30, 95% CI 1.20-4.40) [26].
In the meantime, Tenkanen et al. reported that risk factors for coronary artery disease such as smoking and obesity facilitated physiologic and metabolic disturbances by circadian rhythm disruption following shift work [27]. According to the study, shift work reduces fibrinolytic activity and increases plaque formation. As smoking and obesity reduce fibrinolysis and increase the fibrinogen level and ability of platelets to aggregate, they accelerate the adverse process caused by night work. Meanwhile, the smoking rate is higher in shift workers than day time workers [9]. According to the results of this study, the proportions of current smokers and former smokers were higher in the night workers (44.3% and 16.4%, respectively) than in the other workers (32.6% and 10.2%, respectively). Shift work is associated with an increase in BMI, body weight, and comorbidity of obesity [28]. Although we did not measure BMI in this study, the percentage of those who were diagnosed with obesity was higher in the night workers (2.8%) than in workers who did not do night work (1.7%).
Studies on shift work and cardiovascular diseases have also been conducted in Korea. Ha and Park demonstrated an association between the duration of shift work and metabolic risk factors of cardiovascular diseases in a study on 226 female nurses and 134 male employees in a manufacturing company. The researchers found that an increase in shift work duration leads to a statistically significant increase in blood pressure, serum cholesterol level, and WHR [13]. In addition, Lee and Kim found significant increases in the cardiovascular and digestive symptoms in 1,875 female shift workers [14]. In a more recent study, Ye et al. analyzed 254 female workers and suggested that the OR of metabolic syndrome in shift workers was as high as 6.30 (95% CI 1.24-32.15) [15]. Nevertheless, the above studies had a small subject size, or focused only on a specific sex or occupation types.
This study has several limitations. First, being a cross-sectional study, it is difficult to determine causal relationship between variables through this study. Second, as the study was based on a survey, we were not able to collect objective measures such as blood pressure, BMI, and serum cholesterol. Moreover, information about cardiovascular diseases, night work and other general and occupational characteristics was obtained by self-report survey, which might lead to a possibility for recall bias. Finally, to calculate cumulative night work, we multiplied the number of night work done by the number of months worked. However, as the number of months worked is not exactly same as the duration of night work, cumulative night work may not have produced accurate estimates.
In spite of these limitations, this study is important in that this study is an epidemiologic study that identified an association between cardiovascular diseases and night work with adjustment for several possible confounders using national survey data representative of the Korean population.

Conclusions

Overall, our data showed an increased risk of cardiovascular diseases among paid workers who did night work, and higher cumulative night work demonstrated an increased risk of cardiovascular diseases. But the results might have recall bias and should be interpreted with caution because the exposure variable and independent variables were collected from self-reported survey.
For future research, prospective studies are needed to demonstrate the causal association between the variables. In addition, an analysis specific to night work with more detailed variables (e.g., duration, intensity, direction, and type of shift work) is necessary.

Notes

Competing interests

The authors declare that they have no competing interests.

Acknowledgements

This study was supported by the Occupational Safety and Health Research Institute (OSHRI), Korea Occupational Safety and Health Agency (KOSHA), South Korea.

Authors' contributions

SBK and SP designed the research. SP, JN and JKL performed statistical analysis. SBK and SP interpreted the data and wrote the manuscript. HTK and SSO critically revised the manuscript. All authors read and approved the final manuscript.

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