Choriocarcinoma associated with a normal pregnancy is very rare. In choraiocarcinoma associated with a normal pregnancy, diagnosis is late, and prognosis may be poor due to widespread metastases. So at delivery, careful examinations for abnormal placentas are needed, and if diagnosis is confirmed, intensive care is needed. We present a case of choriocarcinoma arising from placenta at 35th week of pregnancy and 3 months later, requiring emergency hysterectomy due to severe vaginal bleeding and combination chemotherapy (EMA CO) with review of literatures.