Journal List > Korean J Gynecol Oncol Colposc > v.13(4) > 1123495

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Choi, Kim, and Park: Expression of C-MYC, C-RAS, C-ERB B-2 Oncogenes and P53 Gene in Hydatidiform Mole
Original Article

Korean Journal of Gynecologic Oncology and Colposcopy 2002; 13(4): 336-341.

Published online: 12 March 2019

DOI: https://doi.org/10.3802/kjgoc.2002.13.4.336

Expression of C-MYC, C-RAS, C-ERB B-2 Oncogenes and P53 Gene in Hydatidiform Mole

Ho Sun Choi, Seok Mo Kim, Chang Soo Park

Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea.

Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.

Copyright © Korean Society of Gynecologic Oncology and Colposcopy

Abstract

OBJECTIVE

To date early predictors for the development of persistent gestational trophoblastic disease (PGTD) after evacuation of a complete hydatidiform mole were not known. The purpose of this study was to investigate whether there is a correlation between oncogene expression and PGTD after evacuation of molar pregnancy.

METHODS

The expression of c-myc, c-ras, c-erb B-2 oncogene and p53 gene product in paraffin-embedded trophoblastic tissues using immunohistochemical staining were investigated retrospectively. We compared 20 cases of PGTD group with 20 cases of spontaneous regression group after molar evacuation.

RESULTS

Expression of p53 gene was in 25% of regression group while it was detected in 15% of PGTD group. The c-myc, c-ras, c-erb B-2 oncogene product was detected in 80%, 20%, 40% of regression group while it was detected in 75%, 15%, 65% of PGTD group respectively.

CONCLUSION

This result showed that correlation between c-myc, c-ras, c-erb B-2 and p53 gene product expression and PGTD is not significant.

Keywords: c-myc, c-ras, c-erb B-2, p53, Hydatidiform mole

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