Journal List > Korean J Gynecol Oncol > v.19(1) > 1123461

Park, Park, Lee, Park, Oh, Roh, and Ha: A case of myxoid malignant fibrous histiocytoma in the pelvic cavity

Abstract

Malignant fibrous histiocytoma (MFH) is the most frequent malignant soft tissue tumor in adults. A primary MFH occurs most commonly in the extremities and the trunk, but rarely in the pelvic cavity. We report a case of malignant fibrous histiocytoma of the unknown origin in the pelvic cavity with a review of the literature. The neoplasm occurred in the pelvic cavity of 53-year-old female who complained of enlarging nontender mass in the lower abdomen. The final diagnosis was based on the pathological report of the surgical specimen.

Figures and Tables

Fig. 1
Abdominal CT scan shows about 10 cm sized heterogeneously enhancing solid mass in pelvic cavity, diffusely attached to anterior wall of uterus and small bowel loops.
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Fig. 2
The gross finding of surgically removed retroperitomeal mass: This tumor measuring 12.5X10X6 cm, 400 mg, is gray-white, fresh mass with multifocal hemorrhagic necrosis.
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Fig. 3
The tumor cells are arranged with short fascicles consisting of pleomorphic spindle cells (H&E, X200).
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Fig. 4
There are pleomorphic spindle cells in myxoid background (H&E, X200).
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Fig. 5
On immunohistochemically, tumor cells are positive for vimentin (vimentin, X400).
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References

1. Kauffman SL, Stout AP. Histiocytic tumors (fibrous xanthoma and histiocytoma) in children. Cancer. 1961. 14:469–482.
crossref
2. Storm FK, Mahvi DM. Diagnosis and management of retroperitoneal soft tissue sarcoma. Ann Surg. 1991. 214:2–10.
3. Ozello L, Stout AP, Murray MR. Cultural characteristics of malignant histiocytoma and fibrous xanthoma. Cancer. 1963. 16:331–344.
4. O'Brien JE, Stout AP. Malignant fibrous xanthoma. Cancer. 1964. 17:1445–1455.
5. Kempson RL, Kyriakos M. Fibroxanthosarcoma of the soft tissues; A type of malignant fibrous histiocytoma. Cancer. 1972. 29:961–976.
6. Randall RL, Albritton KH, Ferney BJ, Layfield L. Malignant fibrous histiocytoma of soft tissue: An abandoned diagnosis. Am J Orthopedics. 2004. 33:602–608.
7. Mairal A, Terrier P, Chibon F, Sastre X, Lecesne A, Aurias A. Loss of chromosome 13 is the most frequent genomic imbalance in malignant fibrous histiocytoma. A comparative genomic hybridization analysis of a series of 30 cases. Cancer Genet Cytogenet. 1999. 111:134–138.
8. Pezzi CM, Rawlings MS Jr, Esgro JJ, Pollock RE, Romsdahl MM. Prognostic factors in 227 patients with malignant fibrous histiocytoma. Cancer. 1992. 69:2098–2103.
crossref
9. Weiss SW, Enzinger FM. Malignant fibrous histiocytoma: An analysis of 200 cases. Cancer. 1978. 41:2250–2266.
10. Gibbs JF, Huang PP, Lee RJ, McGrath B, Brooks J, McKinley B, et al. Malignant fibrous histiocytoma, an institutional review. Cancer Investigation. 2001. 19:23–27.
11. Jonathan JL, Murray EB. Soft tissue sarcoma. Curr Probl Surg. 1996. 33:821–863.
12. Belal A, Kandil A, Allam A, Khafaga Y, El-Husseinv G, El-Enbabv A, et al. Malignant fibrous histiocytoma: A retrospective study of 109 cases. Am J Clin Oncol. 2002. 25:16–22.
13. Lindberg RD, Martin RG, Romsdahl MM, Barkley HT Jr. Conservative surgery and post operative radiotherapy in 300 adults with soft tissue sarcoma. Cancer. 1981. 47:2391–2397.
14. Blitzer A, Lawson W, Zak FG, Biller HF, Som ML. Clinical-pathological determinants in prognosis of fibrous histiocytoma of the head and neck. Laryngoscope. 1981. 91:2053–2070.
15. Mcgrath PC, Neifeld JP, Lawrence W Jr, DeMay RM, Kay S, Horsley JS 3rd, et al. Improved survival following complete excision of retroperitoneal sarcomas. Ann Surg. 1984. 200:200–204.
crossref
16. Leite C, Goodwin JW, Sinkovics JG, Baker LH, Benjamen R. Chemotherapy of malignant fibrous histiocytoma. A Southwest Oncology Group Report. Cancer. 1997. 40:2010–2014.
17. Patel SR, Plaqer C, Papadopoulos NE, Benjamin RS. Myxoid malignant fibrous histiocytoma: Experience with chemotherapy. Am J Clin Oncol. 1995. 8:528–531.
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