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Kim, Moon, Shin, Suh, Yoon, and Choi: Rb pathway alteration and E2F-1 expression in epithelial ovarian cancer
Original Article

Korean Journal of Gynecologic Oncology 2007; 18(4): 299-307.

Published online: 12 March 2019

DOI: https://doi.org/10.3802/kjgo.2007.18.4.299

Rb pathway alteration and E2F-1 expression in epithelial ovarian cancer

Sung Hee Kim, Soo Hyeon Moon, Su Il Shin, Dong Soo Suh, Man Soo Yoon, Kyung Un Choi

Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea.

Department of Pathology, College of Medicine, Pusan National University, Busan, Korea.

msyoon@pusan.ac.kr

Copyright © Korean Society of Gynecologic Oncology and Colposcopy

Abstract

OBJECTIVE

To evaluate the clinicopathological implications of Rb pathway alteration and E2F-1 expression in Epithelial ovarian cancer using immunohistochemical staining.

METHODS

Tissue samples (n=72) were collected after staging operation between 1998 and 2004.

RESULTS

In 72 cases, the overall expression of pRb, and E2F-1 were 59.7% (43/72), and 58.3% (42/72), respectively. pRb expression was inversely correlated with stage, histologic grade and mitotic index. E2F-1 expression was correlated with advanced stages, high grade, mitotic index, Ki-67 labeling index (LI).

CONCLUSION

We suggest that Rb pathway alteration and E2F-1 expression could play roles as a new prognostic factors in Epithelial ovarian cancer.

Keywords: Epithelial ovarian cancer, Rb pathway alteration, E2F-1 expression

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