Recently, advances and complexity in the treatment of gynecologic cancer cause not only improvement of tumor response and survival but also increase of interest in quality of life (QOL). However, there were relatively few research studies that reported data on QOL in gynecologic cancer patients and the impact of various treatments on QOL in the patients. Considering high morbidity and severe risk of QOL in gynecologic cancer patients, more focus and researches have to be done in issues of QOL. Especially, comprehensive-physical, emotional, social, spiritual-assessments with valid QOL assessment tool should be taken into account in multi-center clinical trials and development of intervention programs for gynecologic cancer patients.