Comparison of Macular Retinal Thickness among Four Optical Coherence Tomography Devices in Healthy Young Subjects

Soo Yeon Cho; Young Hoon Hwang

doi:10.3341/jkos.2019.60.5.434

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Cho and Hwang: Comparison of Macular Retinal Thickness among Four Optical Coherence Tomography Devices in Healthy Young Subjects

Original Article

Journal of the Korean Ophthalmological Society 2019; 60(5): 434-439.

Published online: 15 May 2019

DOI: https://doi.org/10.3341/jkos.2019.60.5.434

Comparison of Macular Retinal Thickness among Four Optical Coherence Tomography Devices in Healthy Young Subjects

Soo Yeon Cho, MD, Young Hoon Hwang, MD, PhD

Myung-Gok Eye Research Institute, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, Korea.

Address reprint requests to Young Hoon Hwang, MD, PhD. Myung-Gok Eye Research Institute, Kim's Eye Hospital, #1 Yeongsin-ro 34-gil, Yeongdeungpo-gu, Seoul 07301, Korea. Tel: 82-2-2639-7777, Fax: 82-2-2633-3976, brainh@hanmail.net

Received 8 August 2018 Revised 22 September 2018 Accepted 17 April 2019

The Korean Ophthalmological Society

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

This study was performed to compare macular retinal thickness measured by four different optical coherence tomography (OCT) devices.

Methods

Macular retinal thicknesses were measured in 32 healthy eyes of 32 subjects by using Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, CA, USA), Spectralis OCT (Heidelberg engineering, Heidelberg, Germany), Topcon DRI OCT (Topcon Corp., Tokyo, Japan), and RS-3000 Advance OCT (Nidek, Co., Ltd., Gamagori, Japan). Macular retinal thickness measurements were compared among the devices.

Results

Average macular retinal thickness ranged 288.7 to 313.3 µm (p < 0.01). Differences in average macular retinal thickness among the devices ranged from 0.7 to 27.3 µm; the limit of agreement (LoA) ranged from 9.7 to 24.4 µm. Among the devices, comparison between Spectralis OCT and RS-3000 Advance OCT showed the smallest difference in average macular retinal thickness (mean, 0.7 µm) and the narrowest LoA (−6.4 to 3.3 µm).

Conclusions

Macular retinal thickness measured by four different OCT devices showed different values. However, values obtained by Spectralis OCT and RS-3000 Advance OCT showed good agreement.

Keywords: Macula, Optical coherence tomography, Retina

Figures and Tables

Figure 1

Bland-Altman plots for agreement of macular retinal thickness as measured by different optical coherence tomography (OCT) devices. Upper and lower dashed lines indicate limit of agreement and middle dashed lines present mean difference between the devices (A, Cirrus HD-OCT versus Topcon DRI OCT; B, Cirrus HD-OCT versus RS-3000 Advance OCT; C, Cirrus HD-OCT versus Spectralis OCT; D, Topcon DRI OCT versus RS-3000 Advance OCT; E, Topcon DRI OCT versus Spectralis OCT; F, RS-3000 Advance OCT versus Spectralis OCT).

Table 1

Comparison of macular retinal thickness (µm) measured by four different OCT devices

Values are presented as mean ± standard deviation (range) unless otherwise indicated.

OCT = optical coherence tomography; C = Cirrus HD-OCT; T = Topcon DRI OCT; R = RS-3000 Advance OCT; S = Spectralis OCT.

^*Repeated measures analysis of variance.

Table 2

Agreement of average macular retinal thickness (µm) as measured by different OCT devices

OCT = optical coherence tomography; LoA = limit of agreement (mean difference ± 2 standard deviation of difference).

^*Pearson's correlation coefficient between mean and difference.

Table 3

Pearson's correlation coefficients (p-values) among average macular retinal thicknesses measured by different OCT devices

OCT = optical coherence tomography.

Notes

^{Conflicts of Interest} The authors have no conflicts to disclose.

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