Pharmacotherapy for Smoking Cessation in Patients with Schizophrenia

Sung-Jin Kim; Do-Un Jung; You-Na Kim

doi:10.16946/kjsr.2018.21.1.21

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Kim, Jung, and Kim: Pharmacotherapy for Smoking Cessation in Patients with Schizophrenia

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Korean Journal of Schizophrenia Research 2018; 21(1): 21-27.

Published online: 30 April 2018

DOI: https://doi.org/10.16946/kjsr.2018.21.1.21

Pharmacotherapy for Smoking Cessation in Patients with Schizophrenia

Sung-Jin Kim, MD, Do-Un Jung, MD, PhD, You-Na Kim, MD

Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Address for correspondence: Do-Un Jung, Department of Psychiatry, Busan Paik Hospital, Inje University College of Medicine, 75 Bokji-ro, Busanjin-gu, Busan 47392, Korea. Tel: 051-890-6189, Fax: 051-894-2532, gabriel.jdu@gmail.com

Received 2 January 2018 Revised 13 March 2018 Accepted 16 March 2018

Korean Society for Schizophrenia Research

Abstract

Schizophrenia is a major chronic mental illness with various symptoms that is often accompanied by substance use disorders. Patients with schizophrenia have a higher smoking rate than the general population and a lower smoking cessation success rate. Further, their motivation for smoking cessation is often low. Individuals with schizophrenia that are past or present cigarette smokers are more difficult to treat in terms of psychotic symptoms, are more likely to have physical illnesses, and have higher mortality rates. A variety of treatments, both pharmacological and non-pharmacological, are used to aid smoking cessation in patients with schizophrenia. Among these, bupropion, varenicline, and nicotine replacement therapy can be safely used in patients with schizophrenia, and several studies have demonstrated their effects. Cigarette smoking is an important health problem. The study of smoking cessation in individuals with schizophrenia may help improve their ability to function and their quality of life through active evaluation and treatment.

Keywords: Schizophrenia, Smoking, Nicotine, Drug therapy

Figures and Tables

Table 1

Summary of studies on effects of smoking treatment medications in patients with schizophrenia

BUP : bupropion, CBT : cognitive behavior therapy, CO : carbon monoxide, CON : control, FTND : Fagerstrom Test for Nicotine Dependence, FTQ : Fagerstrom Tolerance Questionnaire, MA±SD : participants' mean age and standard deviation, M:F : ratio of male to female, MI : motivational interviewing, mCEQ : modified Cigarette Evaluation Questionnaire, mNWS : Minnesota Nicotine Withdrawal scale, N : number of participants, PLA : placebo, QSU-brief : brief Questionnaire of Smoking Urge, RC : routine care, RCT : randomized controlled trial, RMQSQ : Readiness and Motivation to Quit Smoking Questionnaire, TNP : transdermal nicotine patch, T-QSU : Tiffany Questionnarie for Smoking Urges, VA : varenicline, WSWS : Wisconsin Smoking Withdrawal Scale

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