Journal List > J Korean Orthop Assoc > v.54(2) > 1121862

Oh, Seo, and Jeong: Diagnostic Accuracy of Imaging Study and the Impact of Clinical Risk Factors on the Presence of Residual Tumor Following Unplanned Excision of Soft Tissue Sarcomas

Abstract

Purpose

This study examined the diagnostic accuracy of an imaging study to find the factors that affect the presence of residual tumors after an unplanned excision of sarcomas.

Materials and Methods

Ninety-eight patients, who underwent a re-excision after unplanned surgery between January 2008 and December 2014, were enrolled in this study. Magnetic resonance imaging (MRI) was performed before reoperation in all patients. Positron emission tomography (PET)-computed tomography was performed on 54 patients. A wide re-excision and histology diagnosis were performed in all cases. The clinical variables were evaluated using univariate logistic regression and multivariate logistic regression.

Results

The presence of a deep-seated tumor increases the risk of remnant tumors (odds ratio: 3.21, p=0.02, 95% confidence interval: 1.25–8.30). The sensitivity for detecting residual tumors is high in MRI (sensitivity 0.79).

Conclusion

Deep-seated tumors have a significantly higher risk of remnant tumors. Because the negative predictive value of MRI and PET scans is very low, reoperation should be performed regardless of a negative result.

Figures and Tables

Table 1

Patient and Tumor Characteristics

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Values are presented as median (range) or number (%). *International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3). N/A: not applicable.

Table 2

Univariate and Multivariate Logistic Regression of Clinical Risk Factors

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OR, odds ratio; CI, confidence interval.

Table 3

Comparison of the Parameters between MRI and PET-CT

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MRI, magnetic resonance interval; PET-CT, positron emission tomography-computed tomography; PPV, positive predictive value; PPV, negative predictive value.

Notes

CONFLICTS OF INTEREST The authors have nothing to disclose.

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Sung Wook Seo
https://orcid.org/0000-0001-9048-0367

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