Journal List > J Korean Fract Soc > v.32(2) > 1121349

Jo, Lee, Lee, Lee, Kim, Park, and Cho: Results of Exchange Nailing in Hypertrophic Nonunion of Femoral Shaft Fracture Treated with Nailing

Abstract

Purpose

This study examined the outcomes of exchange nailing for the hypertrophic nonunion of femoral shaft fractures treated with intramedullary nailing as well as the factors affecting the treatment outcomes.

Materials and Methods

From January 1999 to March 2015, 35 patients, who had undergone intramedullary nailing with a femoral shaft fracture and underwent exchange nailing due to hypertrophic nonunion, were reviewed. This study investigated the time of union and complications, such as nonunion after exchange nailing, and analyzed the factors affecting the results.

Results

Bone union was achieved in 31 cases (88.6%) after exchange nailing and the average bone union period was 22 weeks (14–44 weeks). Complications included persistent nonunion in four cases, delayed union in one case, and superficial wound infection in one case. All four cases with nonunion were related to smoking, three of them were distal shaft fractures, and one was a midshaft fracture with underlying disease.

Conclusion

Exchange nailing produced satisfactory results as the treatment of hypertrophic nonunion after intramedullary nailing. Smoking is considered a factor for continuing nonunion even after exchange nailing. In the case of a distal shaft, where the intramedullary fixation is relatively weak, additional efforts are needed for stability.

References

1. Crowley DJ, Kanakaris NK, Giannoudis PV. Femoral diaphyseal aseptic nonunions: is there an ideal method of treatment? Injury. 38(Suppl 2):S55–63. 2007.
crossref
2. Lynch JR, Taitsman LA, Barei DP, Nork SE. Femoral nonunion: risk factors and treatment options. J Am Acad Orthop Surg. 16:88–97. 2008.
crossref
3. Banaszkiewicz PA, Sabboubeh A, McLeod I, Maffulli N. Femoral exchange nailing for aseptic nonunion: not the end to all problems. Injury. 34:349–356. 2003.
crossref
4. Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P. Nonunion of the femoral diaphysis. The influence of reaming and nonsteroidal anti-inflammatory drugs. J Bone Joint Surg Br. 82:655–658. 2000.
5. Winquist RA, Hansen ST Jr, Clawson DK. Closed intramedullary nailing of femoral fractures. A report of five hundred and twenty cases. J Bone Joint Surg Am. 66:529–539. 1984.
crossref
6. Weber BG, Brunner C. The treatment of nonunions without electrical stimulation. Clin Orthop Relat Res. 161:24–32. 1981.
crossref
7. Lee KB, Moon ES, Song EK, Choi J, Jung ST. Treatment of the nonunion of femur shaft fractures after interlocking intramedullary nailing. J Korean Fract Soc. 15:497–503. 2002.
crossref
8. Park K, Kim K, Choi YS. Comparison of mechanical rigidity between plate augmentation leaving the nail in situ and interlocking nail using cadaveric fracture model of the femur. Int Orthop. 35:581–585. 2011.
crossref
9. Wang Z, Liu C, Liu C, Zhou Q, Liu J. Effectiveness of exchange nailing and augmentation plating for femoral shaft nonunion after nailing. Int Orthop. 38:2343–2347. 2014.
crossref
10. Lin CJ, Chiang CC, Wu PK, et al. Effectiveness of plate augmentation for femoral shaft nonunion after nailing. J Chin Med Assoc. 75:396–401. 2012.
crossref
11. Yang KH, Kim JR, Park J. Nonisthmal femoral shaft nonunion as a risk factor for exchange nailing failure. J Trauma Acute Care Surg. 72:E60–64. 2012.
crossref
12. Jung HG, Kim DJ, Kim BH, Chung YY. Treatment of the femoral shaft nonunion occurred after intramedullary nailing. J Korean Orthop Assoc. 42:653–658. 2007.
crossref
13. Hak DJ, Lee SS, Goulet JA. Success of exchange reamed intramedullary nailing for femoral shaft nonunion or delayed union. J Orthop Trauma. 14:178–182. 2000.
crossref
14. Hierholzer C, Glowalla C, Herrler M, et al. Reamed intramedullary exchange nailing: treatment of choice of aseptic femoral shaft nonunion. J Orthop Surg Res. 9:88. 2014.
crossref
15. Webb LX, Winquist RA, Hansen ST. Intramedullary nailing and reaming for delayed union or nonunion of the femoral shaft. A report of 105 consecutive cases. Clin Orthop Relat Res. 212:133–141. 1986.
16. Weresh MJ, Hakanson R, Stover MD, Sims SH, Kellam JF, Bosse MJ. Failure of exchange reamed intramedullary nails for ununited femoral shaft fractures. J Orthop Trauma. 14:335–338. 2000.
crossref
17. Eom TW, Kim JJ, Oh HK, Kim JW. Challenge to treat hypertrophic nonunion of the femoral shaft: the Poller screw augmentation technique. Eur J Orthop Surg Traumatol. 26:559–563. 2016.
crossref
18. Park J, Yang KH. Indications and outcomes of augmentation plating with decortication and autogenous bone grafting for femoral shaft nonunions. Injury. 44:1820–1825. 2013.
crossref
19. Kim JW, Yoon YC, Oh CW, Han SB, Sim JA, Oh JK. Exchange nailing with enhanced distal fixation is effective for the treatment of infraisthmal femoral nonunions. Arch Orthop Trauma Surg. 138:27–34. 2018.
crossref
20. Donigan JA, Fredericks DC, Nepola JV, Smucker JD. The effect of transdermal nicotine on fracture healing in a rabbit model. J Orthop Trauma. 26:724–727. 2012.
crossref
21. Kim SS, Sohn SK, Kim CH, Lee MJ, Wang L. Cause and treatment of the nonunion of femoral shaft fracture after interlocking intramedullary nailing. J Korean Fract Soc. 20:141–148. 2007.
crossref
22. Moghaddam A, Zimmermann G, Hammer K, Bruckner T, Grützner PA, von Recum J. Cigarette smoking influences the clinical and occupational outcome of patients with tibial shaft fractures. Injury. 42:1435–1442. 2011.
crossref
23. Berman D, Oren JH, Bendo J, Spivak J. The effect of smoking on spinal fusion. Int J Spine Surg. 11:29. 2017.
crossref
24. Cha SM, Shin HD, Ahn KJ. Prognostic factors affecting union after ulnar shortening osteotomy in ulnar impaction syndrome: a retrospective case-control study. J Bone Joint Surg Am. 99:638–647. 2017.
25. Schmitz MA, Finnegan M, Natarajan R, Champine J. Effect of smoking on tibial shaft fracture healing. Clin Orthop Relat Res. 365:184–200. 1999.
crossref

Fig. 1.
(A) Fracture site gap is shown after exchange nailing. (B) More deep insertion of the nail. (C) Distal screw fixation first, followed by pull out of the nail reversely. (D) Fracture site gap is reduced. (E) Proximal screw fixation finally.
jkfs-32-83f1.tif
Fig. 2.
A 62-year-old male smoker. He had uncontrolled diabetes and blood pressure. (A) X-ray shows a left femur midshaft fracture (Winquist-Hansen Type I). (B) Initially, intramedullary nailing was done. (C) After 22 months, the X-ray shows hypertrophic nonunion. (D) Exchange nailing is done. (E) Finally, nonunion is presented.
jkfs-32-83f2.tif
Table 1.
Patients Demographic Data
Case No. Age (yr) Sex Combined injury Location of fracture W Winquist−Hans classification sen n Comorbidit ty Smoking gSoft tissue injury M to onths injury o nonunion Weeks exchange nail to union
1 32 M   Distal shaft I   Y Closed 9 18
2 46 F   Midshaft II   Y Closed 10 28
3 25 M Acetabular Fx. Midshaft I   N Closed 9 32
4 52 M   Proximal shaft I   Y Closed 20 32
5 27 M Both tibia Fx. Midshaft I   N Open 15 36
6 58 M   Distal shaft 0 DM N Closed 9 32
7 62 M   Midshaft I HTN, DM Y Closed 22 Nonunion
8 24 M   Proximal shaft III   N Closed 10 16
9 37 M   Midshaft I   N Closed 9 32
10 45 M Patella Fx. Midshaft 0 HTN N Closed 12 32
11 44 M   Distal shaft I   Y Closed 10 Nonunion
12 37 M Tibio-fibular Fx. Patella Fx. Midshaft II   N Closed 9 44 (delayed union)
13 25 F   Midshaft 0   N Closed 9 14
14 22 M   Distal shaft I   N Closed 10 30
15 25 M Acetabular Fx. Proximal shaft I   N Closed 12 28
16 56 M   Midshaft III HTN Y Closed 16 36
17 65 M Tibia Fx. Midshaft I DM N Open 9 36
18 62 F   Midshaft II HTN, DM N Closed 9 32
19 44 M   Proximal shaft I   N Closed 10 26
20 43 F   Distal shaft 0   Y Closed 12 Nonunion
21 28 M   Midshaft I   N Closed 15 16
22 20 F   Midshaft II   N Closed 9 14
23 33 M   Midshaft I   N Closed 9 16
24 27 M   Distal shaft I   N Closed 9 28
25 25 M Patella Fx. Midshaft III   N Closed 12 24
26 29 F   Midshaft 0   N Closed 24 28
27 32 F   Distal shaft I   N Closed 12 28
28 42 F   Midshaft I   Y Closed 20 24
29 56 M Acetabular Fx. Midshaft II HTN N Closed 9 36
30 25 M   Distal shaft I   N Closed 12 28
31 48 M   Midshaft 0   Y Closed 16 36
32 39 F Patella Fx. Distal shaft I   N Closed 12 32
33 43 F   Distal shaft II   Y Open 9 Nonunion
34 28 M   Midshaft I   N Closed 9 16
35 24 M   Proximal shaft I   N Closed 12 28

M: male, F: female, Fx.: fracture, DM: diabetes mellitus, HTN: hypertension, Y: yes, N: no.

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