Abstract
Purpose
This study examined the outcomes of exchange nailing for the hypertrophic nonunion of femoral shaft fractures treated with intramedullary nailing as well as the factors affecting the treatment outcomes.
Materials and Methods
From January 1999 to March 2015, 35 patients, who had undergone intramedullary nailing with a femoral shaft fracture and underwent exchange nailing due to hypertrophic nonunion, were reviewed. This study investigated the time of union and complications, such as nonunion after exchange nailing, and analyzed the factors affecting the results.
Results
Bone union was achieved in 31 cases (88.6%) after exchange nailing and the average bone union period was 22 weeks (14–44 weeks). Complications included persistent nonunion in four cases, delayed union in one case, and superficial wound infection in one case. All four cases with nonunion were related to smoking, three of them were distal shaft fractures, and one was a midshaft fracture with underlying disease.
Conclusion
Exchange nailing produced satisfactory results as the treatment of hypertrophic nonunion after intramedullary nailing. Smoking is considered a factor for continuing nonunion even after exchange nailing. In the case of a distal shaft, where the intramedullary fixation is relatively weak, additional efforts are needed for stability.
References
1. Crowley DJ, Kanakaris NK, Giannoudis PV. Femoral diaphyseal aseptic nonunions: is there an ideal method of treatment? Injury. 38(Suppl 2):S55–63. 2007.
2. Lynch JR, Taitsman LA, Barei DP, Nork SE. Femoral nonunion: risk factors and treatment options. J Am Acad Orthop Surg. 16:88–97. 2008.
3. Banaszkiewicz PA, Sabboubeh A, McLeod I, Maffulli N. Femoral exchange nailing for aseptic nonunion: not the end to all problems. Injury. 34:349–356. 2003.
4. Giannoudis PV, MacDonald DA, Matthews SJ, Smith RM, Furlong AJ, De Boer P. Nonunion of the femoral diaphysis. The influence of reaming and nonsteroidal anti-inflammatory drugs. J Bone Joint Surg Br. 82:655–658. 2000.
5. Winquist RA, Hansen ST Jr, Clawson DK. Closed intramedullary nailing of femoral fractures. A report of five hundred and twenty cases. J Bone Joint Surg Am. 66:529–539. 1984.
6. Weber BG, Brunner C. The treatment of nonunions without electrical stimulation. Clin Orthop Relat Res. 161:24–32. 1981.
7. Lee KB, Moon ES, Song EK, Choi J, Jung ST. Treatment of the nonunion of femur shaft fractures after interlocking intramedullary nailing. J Korean Fract Soc. 15:497–503. 2002.
8. Park K, Kim K, Choi YS. Comparison of mechanical rigidity between plate augmentation leaving the nail in situ and interlocking nail using cadaveric fracture model of the femur. Int Orthop. 35:581–585. 2011.
9. Wang Z, Liu C, Liu C, Zhou Q, Liu J. Effectiveness of exchange nailing and augmentation plating for femoral shaft nonunion after nailing. Int Orthop. 38:2343–2347. 2014.
10. Lin CJ, Chiang CC, Wu PK, et al. Effectiveness of plate augmentation for femoral shaft nonunion after nailing. J Chin Med Assoc. 75:396–401. 2012.
11. Yang KH, Kim JR, Park J. Nonisthmal femoral shaft nonunion as a risk factor for exchange nailing failure. J Trauma Acute Care Surg. 72:E60–64. 2012.
12. Jung HG, Kim DJ, Kim BH, Chung YY. Treatment of the femoral shaft nonunion occurred after intramedullary nailing. J Korean Orthop Assoc. 42:653–658. 2007.
13. Hak DJ, Lee SS, Goulet JA. Success of exchange reamed intramedullary nailing for femoral shaft nonunion or delayed union. J Orthop Trauma. 14:178–182. 2000.
14. Hierholzer C, Glowalla C, Herrler M, et al. Reamed intramedullary exchange nailing: treatment of choice of aseptic femoral shaft nonunion. J Orthop Surg Res. 9:88. 2014.
15. Webb LX, Winquist RA, Hansen ST. Intramedullary nailing and reaming for delayed union or nonunion of the femoral shaft. A report of 105 consecutive cases. Clin Orthop Relat Res. 212:133–141. 1986.
16. Weresh MJ, Hakanson R, Stover MD, Sims SH, Kellam JF, Bosse MJ. Failure of exchange reamed intramedullary nails for ununited femoral shaft fractures. J Orthop Trauma. 14:335–338. 2000.
17. Eom TW, Kim JJ, Oh HK, Kim JW. Challenge to treat hypertrophic nonunion of the femoral shaft: the Poller screw augmentation technique. Eur J Orthop Surg Traumatol. 26:559–563. 2016.
18. Park J, Yang KH. Indications and outcomes of augmentation plating with decortication and autogenous bone grafting for femoral shaft nonunions. Injury. 44:1820–1825. 2013.
19. Kim JW, Yoon YC, Oh CW, Han SB, Sim JA, Oh JK. Exchange nailing with enhanced distal fixation is effective for the treatment of infraisthmal femoral nonunions. Arch Orthop Trauma Surg. 138:27–34. 2018.
20. Donigan JA, Fredericks DC, Nepola JV, Smucker JD. The effect of transdermal nicotine on fracture healing in a rabbit model. J Orthop Trauma. 26:724–727. 2012.
21. Kim SS, Sohn SK, Kim CH, Lee MJ, Wang L. Cause and treatment of the nonunion of femoral shaft fracture after interlocking intramedullary nailing. J Korean Fract Soc. 20:141–148. 2007.
22. Moghaddam A, Zimmermann G, Hammer K, Bruckner T, Grützner PA, von Recum J. Cigarette smoking influences the clinical and occupational outcome of patients with tibial shaft fractures. Injury. 42:1435–1442. 2011.
23. Berman D, Oren JH, Bendo J, Spivak J. The effect of smoking on spinal fusion. Int J Spine Surg. 11:29. 2017.
24. Cha SM, Shin HD, Ahn KJ. Prognostic factors affecting union after ulnar shortening osteotomy in ulnar impaction syndrome: a retrospective case-control study. J Bone Joint Surg Am. 99:638–647. 2017.