Journal List > Dement Neurocogn Disord > v.13(4) > 1120745

Dement Neurocogn Disord. 2014 Dec;13(4):89-93. Korean.
Published online Dec 31, 2014.
© 2014 Korean Dementia Association
Comparison of Behavioral and Psychological Symptoms between Early and Late Onset Alzheimer's Disease According to the Progression of Dementia
Yeo-Ju Yoon, M.A.,* Eun-Joo Kim, M.D., and Chang Hee Hong, Ph.D.
*Department of Psychiatry, Inje university paik-hospital, Busan, Korea.
Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, Korea.
Department of Psychology, Pusan National University, Busan, Korea.

Address for correspondence: Changhee Hong, Ph.D. Department of Psychology, Pusan National University, 2 Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 609-735, Korea. Tel: +82-51-510-2144, Fax: +82-51-581-1457, Email:
Received Nov 04, 2014; Revised Dec 14, 2014; Accepted Dec 14, 2014.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to investigate behavioral and psychological symptoms of dementia (BPSD) measured by caregiver-administered neuropsychiatric inventory (CGA-NPI) as a function of dementia severity in early onset (EOAD) versus late onset Alzheimer's disease (LOAD). A total of 113 patients with AD consisting of 49 patients with EOAD and 64 patients with LOAD were enrolled consecutively. General cognitive function and severity of dementia were assessed by the Korean version of mini-mental status examination and clinical dementia rating (CDR), respectively. In the mild stage (CDR 0.5-1), LOAD patients had a significantly higher total CGA-NPI score than EOAD patients. Subgroup analysis demonstrated that disinhibition and night-time behavior were more common and severe in the LOAD group than the EOAD group. However, in the moderate to severe stage (CDR 2-3), EOAD patients had a significantly higher total CGA-NPI score with higher subscores in hallucination, agitation/aggression, irritability/lability, aberrant motor behavior, and appetite/eating change. This study suggested that the heterogeneity of BPSD in AD might be accounted for by dementia severity as well as age at symptoms onset.

Keywords: Behavioral and psychological symptoms of dementia; Early onset Alzheimer's diseases; Agitation; Caregiver-administered neuropsychiatric inventory


Fig. 1
Comparison of total score of CGA-NPI between EOAD and LOAD according to the progression of dementia.
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Table 1
Demographic and clinical features between EOAD and LOAD group
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Table 2
Subscale score of CGA-NPI between EOAD and LOAD according to the progression of dementia
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Table 3
Comparison of subscale score of CGA-NPI between EOAD and LOAD according to the progression of dementia
Click for larger image

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