Journal List > Dement Neurocogn Disord > v.13(3) > 1120733

Han, Joo, Kang, Ha, and Yang: Non-paraneoplastic Autoantibody-negative Limbic Encephalitis Characterized by Mild Memory Impairment: A Case Report

Abstract

Encephalitis that primarily involves limbic system structures such as the hippocampus and parahippocampal gyrus has been described in early papers, most commonly characterized by a subacute progressive impairment of short-term memory, psychiatric features and seizures. While these findings might be caused by viral infections or systemic autoimmune disorders, many patients with limbic encephalitis have an immune-mediated etiology (paraneoplastic or not) characterized with serum or CSF antineuronal antibodies. This case reports about non-paraneoplastic autoantibody-negative limbic encephalitis in which there are no detection of antigens and no evidence of tumors.

Figures and Tables

Fig. 1
Axial brain MR T2-weighted image (T2WI) and fluid-attenuated inversion recovery (FLAIR) image show increased signal intensity in both medial temporal lobe (A, C). T1-weighted image (T1WI), Gadolium (Gd)-eahauced T1-weighted MRI and DWI study shows no hyperintensity on bilateral temporal lobes with isointensities on ADC map (B, D, E, F).
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Fig. 2
Brain FDG PET shows increased FDG uptake in the both medial temporal lobes, which is much worse on the left side.
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Fig. 3
EEG monitoring shows no epileptiform discharge.
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Fig. 4
Follow-up MRI after 2 weaks. FLAIR image shows some improvement compared to the previous study.
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