YoungSoon Yang; Inha Hwang; Yong Tae Kwak

doi:10.12779/dnd.2014.13.3.74

Journal List > Dement Neurocogn Disord > v.13(3) > 1120732

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Yang, Hwang, and Kwak: Neuropsychological Characteristics of Wandering in Patients with Drug-naïve Alzheimer's Disease

Original Article

Dementia and Neurocognitive Disorders 2014; 13(3): 74-78.

Published online: 30 September 2014

DOI: https://doi.org/10.12779/dnd.2014.13.3.74

Neuropsychological Characteristics of Wandering in Patients with Drug-naïve Alzheimer's Disease

YoungSoon Yang, M.D.^*, Inha Hwang, M.D.^*, Yong Tae Kwak, M.D.^†

^*Department of Neurology, Seoul Veterans Hospital, Seoul, Korea.

^†Department of Neurology, Hyoja Geriatric Hospital, Yongin, Korea.

Address for correspondence: Yong Tae Kwak, M.D. Department of Neurology, Hyoja Geriatric Hospital, 1-30 Jungbu-daero 874beon-gil, Giheung-gu, Yongin 446-512, Korea. Tel: +82-31-288-0602, Fax: +82-31-288-0539, kwakdr@gmail.com

Received 19 August 2014 Revised 2 September 2014 Accepted 2 September 2014

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background

Wandering represents one of a major problem occurring in patients with Alzheimer's disease (AD). To find the disproportionate neuropsychological deficit and behavioral psychological symptoms in dementia (BPSD) of AD patients with wandering compared to AD patients without wandering, this study examined the set of neuropsychological tests and caregiver-administered neuropsychiatric inventory (CGA-NPI).

Methods

Psychotropic-naïve (drug-naïve) probable AD patients with wandering (64) and without wondering (278) were assessed with the Seoul Neuropsychological Screening Battery, which included measures of memory, intelligence, and executive functioning.

Results

Patients with wandering had lower scores in the Rey-Osterrieth Complex Figure copy, Fist-edge-palm, Alternating hand movement tests compared to patients without wandering. The degree of wandering in AD patients was significantly related with CGA-NPI subdomains of aggression, disinhibition, depression, and delusions.

Conclusion

This study showed that 1) AD patients with wandering have disproportionately cognitive deficit suggesting frontal and right parietal dysfunctions, 2) wanderings are related with specific BPSD. Considering these results, AD patients with wandering may have specific neuronal anatomic substrates related with pathology of Alzheimer.

Keywords: Wandering, Alzheimer, Neuropsycholigical deficit, Drug-naive

Figures and Tables

Table 1

Demograhic and clinical features between AD patients with wandering and without wandering

K-MMSE, Korean Mini-Mental State Examination; CDR, Clinical Dementia Rating Scale; GDS, Geriatric Depression Scale; CGA-NPI, Caregiver-Administered Neuropsychiatric Inventory.

Table 2

Neuropsychological tests between AD patients with wandering and without wandering

^*Statistcial difference was found between AD patients with wandering and without wandering.

K-BNT, Korean version of the Boston Naming Test; SVLT, Seoul Verbal Learning Test; RCFT, Rey-Osterrieth Complex Figure Test; COWAT, Controlled Oral Word Association Test; CWST, Color Word Stroop Test.

Table 3

Wandering-related neuropsychiatric symptom variables with intercept and corresponding weights (B) and probability levels in patients with Alzheimer's disease

^*Multiple regression analysis (R=0.506); Caregiver-administered neuropsychiatric inventory (CGA-NPI) variables are statistically related to wandering.

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