Journal List > Dement Neurocogn Disord > v.13(3) > 1120732

Dement Neurocogn Disord. 2014 Sep;13(3):74-78. Korean.
Published online Sep 30, 2014.  https://doi.org/10.12779/dnd.2014.13.3.74
© 2014 Korean Dementia Association
Neuropsychological Characteristics of Wandering in Patients with Drug-naïve Alzheimer's Disease
YoungSoon Yang, M.D.,* Inha Hwang, M.D.,* and Yong Tae Kwak, M.D.
*Department of Neurology, Seoul Veterans Hospital, Seoul, Korea.
Department of Neurology, Hyoja Geriatric Hospital, Yongin, Korea.

Address for correspondence: Yong Tae Kwak, M.D. Department of Neurology, Hyoja Geriatric Hospital, 1-30 Jungbu-daero 874beon-gil, Giheung-gu, Yongin 446-512, Korea. Tel: +82-31-288-0602, Fax: +82-31-288-0539, Email: kwakdr@gmail.com
Received Aug 19, 2014; Revised Sep 02, 2014; Accepted Sep 02, 2014.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Background

Wandering represents one of a major problem occurring in patients with Alzheimer's disease (AD). To find the disproportionate neuropsychological deficit and behavioral psychological symptoms in dementia (BPSD) of AD patients with wandering compared to AD patients without wandering, this study examined the set of neuropsychological tests and caregiver-administered neuropsychiatric inventory (CGA-NPI).

Methods

Psychotropic-naïve (drug-naïve) probable AD patients with wandering (64) and without wondering (278) were assessed with the Seoul Neuropsychological Screening Battery, which included measures of memory, intelligence, and executive functioning.

Results

Patients with wandering had lower scores in the Rey-Osterrieth Complex Figure copy, Fist-edge-palm, Alternating hand movement tests compared to patients without wandering. The degree of wandering in AD patients was significantly related with CGA-NPI subdomains of aggression, disinhibition, depression, and delusions.

Conclusion

This study showed that 1) AD patients with wandering have disproportionately cognitive deficit suggesting frontal and right parietal dysfunctions, 2) wanderings are related with specific BPSD. Considering these results, AD patients with wandering may have specific neuronal anatomic substrates related with pathology of Alzheimer.

Keywords: Wandering; Alzheimer; Neuropsycholigical deficit; Drug-naive

Tables


Table 1
Demograhic and clinical features between AD patients with wandering and without wandering
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Table 2
Neuropsychological tests between AD patients with wandering and without wandering
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Table 3
Wandering-related neuropsychiatric symptom variables with intercept and corresponding weights (B) and probability levels in patients with Alzheimer's disease
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