Journal List > Dement Neurocogn Disord > v.13(2) > 1120727

Dement Neurocogn Disord. 2014 Jun;13(2):42-45. Korean.
Published online Jun 30, 2014.
© 2014 Korean Dementia Association
The Relationships between Homocysteine Levels and Memory in Early Alzheimer's Disease Patients
Jong-Sik Park, M.A.,* In-Uk Song, M.D.,* Sung-Woo Chung, M.D.,* Yeonwook Kang, Ph.D., and YoungSoon Yang, M.D.
*Department of Neurology, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, Korea.
Department of Psychology, Hallym University, Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Korea.
Department of Neurology, Veterans Hospital, Seoul Medical Center, Seoul, Korea.

Address for correspondence: Sung-Woo Chung, M.D. Department of Neurology, Incheon St. Mary's Hospital, The Catholic University College of Medicine, 56 Dongsu-ro, Bupyeong-gu, Incheon 403-720, Korea. Tel: +82-32-280-5010, Fax: +82-32-280-5244, Email: Address for correspondence: Yeonwook Kang, Ph.D. Department of Psychology, Hallym University, 1 Hallymdaehak-gil, Chuncheon 200-702, Korea. Tel: +82-31-248-1724, Fax: +82-33-256-3424, Email:
Received May 23, 2014; Revised May 30, 2014; Accepted May 30, 2014.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Alzheimer's disease (AD) is a representative neurodegenerative disorder associated with memory disturbance. Recent research has shown that risk factors for cerebrovascular disorders are also causes of dementia. Of these risk factors, hyperhomocysteinemia is well known to be positively correlated with all types of dementias including AD. But it is not clear if there is a difference in the concentration of homocysteine according to subtypes of memory impairment of AD. We performed this study to explore the relationship between homocysteine and memory.


A total of 54 patients (male: 15 patients) to the dementia clinic at our hospital were recruited for this study. All subjects underwent neuropsychological tests including detailed memory function tests and brain magnetic resonance images. The plasma homocysteine level was measured routinely in all patients.


Verbal and visual memories in AD were significantly associated with the concentration of plasma homocysteine. The plasma homocysteine level was significantly correlated with delayed recalls of verbal and visual memories and recognition of visual memory. However, there was no relationship between plasma homocysteine and working memory.


This study showed that plasma homocysteine level was related to the consolidation and retrieval stage of memory in AD. Therefore, we cautiously assumed that control of plasma homocysteine level could contribute to management for the prevention of cognitive impairment.

Keywords: Alzheimer's disease; Memory; Homocysteine


Table 1
Demographic data of subjects
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Table 2
Correlation coefficients between plasma homocysteine level and memory performance in Alzheimer's disease patients
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Table 3
Regression analysis result of plasma homocysteine level and memory performance in Alzheimer's disease patients
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