Journal List > Dement Neurocogn Disord > v.14(3) > 1120318

Dement Neurocogn Disord. 2015 Sep;14(3):135-136. English.
Published online Sep 30, 2015.
© 2015 Korean Dementia Association
Limbic Encephalitis with Hyperintense Cerebrospinal Fluid on Fluid Attenuated Inversion Recovery Images
Inha Hwang,1 In Joong Kim,2 Byung Joon Lee,3 and Sang-Won Ha1
1Department of Neurology, Veterans Health Service Medical Center, Seoul, Korea.
2Department of Radiology, Veterans Health Service Medical Center, Seoul, Korea.
3Department of Pulmonology, Veterans Health Service Medical Center, Seoul, Korea.

Correspondence: Sang-Won Ha, MD, Department of Neurology, Veterans Health Service Medical Center, 53 Jinhwangdo-ro 61-gil, Gangdong-gu, Seoul 05368, Korea. Tel: +82-2-2225-4601, Fax: +82-2-2225-1327, Email:
Received Sep 07, 2015; Revised Sep 11, 2015; Accepted Sep 11, 2015.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

An 83-year-old male was admitted to the emergency department with two days of cognitive impairment. On initial presentation, his neurologic examination showed him to be alert but disoriented with a mini-mental status examination score of zero. An initial CT and diffusion-weighted image of the brain showed no abnormalities. A chest X-ray showed a 3×3 cm mass on left upper lobe. Biopsy confirmed mass to be a squamous cell carcinoma. Examination of the cerebrospinal fluid (CSF) was within normal limits.

Fluid attenuated inversion recovery images (FLAIR) showed suspicious high signal intensity lesion on left medial temporal lobe and hyperintense CSF on right temporal area (Fig. 1A, B, and C). Axial T1- and T2-weighted images showed no abnormality on corresponding same region. Whole-body positron emission tomography (PET) showed glucose uptake on left medial temporal lobe indicating limbic encephalitis. At first glance, hyperintense CSF lesion on right temporal lobe were thought to be more remarkable than left medial temporal lobe lesions, causing confusion to diagnosis. With PET showing glucose uptake on left medial temporal lobe, we could suspect limibic encephalitis.

Fig. 1
Fluid-attenuated inversion recovery images (A), (B), and (C) show hyperintense cerebrospinal fluid (CSF) on right temporal area (arrowhead) and a high signal intensity lesion on left medial temporal area suspicious of limbic encephalitis (B) (arrow). Positron emission tomography-computed tomography images (D) and (E) show an asymmetric increase of fluorodeoxyglucose uptake in the left medial temporal area matching the high signal intensity lesion seen in the image (B, arrow). Gradient recalled echo T2-weighted image (F) shows magnetic susceptibility artifact matching hyperintense CSF, seen in fluid-attenuated inversion recovery image (C, yellow curved line).
Click for larger image

The term "hyperintense CSF" is used to describe failed suppression, or hyperintensity, of CSF on FLAIR of brain.1 Pathologic conditions associated with hyperintense CSF includes subarachnoid hemorrhage, meningitis, and acute infarction following gadolinium administration.1 Some non-pathologic conditions showing hyperintense CSF are images obtained during oxygen inhalation, CSF flow-related artifact.1 Gradient echo imaging showed magnetic susceptibility artifact matching hyperintense CSF seen in FLAIR image (Fig. 1). We reached an agreement that the lesion on FLAIR image is an artifact in the process of nulling CSF signal during acquiring FLAIR image. Knowledge of pathologic conditions of hyperintense CSF needed for correct diagnosis.


Conflicts of Interest:The authors have no financial conflicts of interest.

1. Tha KK, Terae S, Kudo K, Miyasaka K. Differential diagnosis of hyperintense cerebrospinal fluid on fluid-attenuated inversion recovery images of the brain. Part II: non-pathological conditions. Br J Radiol 2009;82:610–614.